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NCT Number: NCT07730060

Intraperitoneal Saline Irrigation in Cesarean Section

The study evaluates the effect of intraperitoneal saline irrigation before abdominal closure during cesarean section on postoperative infectious morbidity and the incidence of paralytic ileus.

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Key information

Conditions

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

About this study

Cesarean section is one of the most commonly performed surgical procedures worldwide. Despite advances in surgical techniques, aseptic measures, and perioperative antibiotic prophylaxis, postoperative complications such as infectious morbidity and paralytic ileus remain significant causes of maternal morbidity, prolonged hospital stay, and increased healthcare costs. Postoperative infectious morbidity may include endometritis, wound infection, pelvic abscess, and febrile morbidity, while paralytic ileus may delay recovery, ambulation, and initiation of oral feeding.

Intraperitoneal saline irrigation has been proposed as a simple and inexpensive intraoperative technique that may reduce postoperative complications. Irrigation may help remove blood clots, tissue debris, vernix caseosa, and bacterial contaminants from the peritoneal cavity, thereby decreasing inflammatory response and the risk of postoperative infection. In addition, reducing intra-abdominal irritation may improve bowel motility and decrease the incidence of postoperative paralytic ileus.

However, the effectiveness of intraperitoneal saline irrigation during cesarean section remains controversial. Some studies have suggested potential benefits in reducing postoperative febrile morbidity and improving recovery, while others reported no significant advantage. Due to the limited and conflicting evidence, further randomized controlled studies are needed to evaluate the role of intraperitoneal saline irrigation in cesarean delivery.

Therefore, this study aims to assess the effect of intraperitoneal saline irrigation in cesarean section on postoperative infectious morbidity and paralytic ileus.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-40 years
  • Elective CS at term ≥37 weeks
  • Singleton pregnancy
  • Intact membranes
  • BMI 18.5 - 34.9 kg/m²

Exclusion criteria

  • Chorioamnionitis or intrauterine infection
  • Prolonged rupture of membranes > 18 hours
  • History of previous abdominal surgery other than CS
  • Immunocompromised patients or on corticosteroids
  • Severe anemia Hb < 8 g/dL
  • Diabetes mellitus or hypertension
  • Placenta previa or accreta spectrum disorders
  • Emergency CS for uterine rupture or severe bleeding
  • Known allergy to normal saline

Treatment and study plan

Intraperitoneal Saline Irrigation

Procedure

Intraperitoneal irrigation with 1000 mL of warm sterile 0.9% normal saline during cesarean section, followed by complete aspiration before abdominal closure.

Primary outcomes

  1. Postoperative infectious morbidity within 6 weeks

    Time frame: 6 Week

    defined as fever ≥ 38°C, wound infection, or endometritis.

  2. Paralytic ileus

    Time frame: baseline

    Time to first passage of flatus in hours, and time to first bowel motion in hours.

Secondary outcomes

  1. Length of hospital stay in days

    Time frame: 6 week

  2. Readmission rate within 6 weeks

    Time frame: 6 week

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Intraperitoneal Saline Irrigation in Cesarean Section: Effect on Postoperative Infectious Morbidity and Paralytic Ileus ,Randomized Controlled Study.

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jul 28, 2026
Registry last updated
Jul 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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