Intraperitoneal Instillation of Levobupivacaine With Morphine Versus Levobupivacaine With Magnesium Sulfate for Postoperative Analgesia

This is a prospective randomized study that included 60 patients and was divided into two equal groups of patients who were scheduled for LC, Ages 18 and 60 years, both sexes, ASA I-II and BMI 19 - 39. Group A received 30 ml levobupivacaine (0.25%) plus 3 mg morphine intraperitoneal at the site of surgery in the bed of the gallbladder via the navel port with the patient in a Trendelenburg position, Group B received 30 ml levobupivacaine (0.25%) plus 50 mg/kg magnesium sulfate in the same pattern as in the A group.

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Key information

Conditions

Post Operative Pain Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

‪Khalid abdelal‬

Sohag, 532, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients who were scheduled for L.C,
Ages 18 and 60 years
ASA I-II and
BMI 19 - 39

Exclusion criteria

Patients with hepatic or renal dysfunction
use of opioids 24 hrs prior to the study
treatment with steroids prior to surgery
drug or alcohol abuse, allergy to any of the study drugs
chronic pain syndrome as a result of neurological disease

Treatment and study plan

intraperitoneal levobupivacaine and morphine

Drug

istillation of the peritoneum with levobupivacaine mixture with morphine

Primary outcomes

reduction of postoperative pain

Time frame: 8 hours

reduction of post operative visual analogue score

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Comparison of Intra-Peritoneal Instillation of Levobupivacaine With Morphine Hydrochloride Versus Levobupivacaine With Magnesium Sulfate for Post-Operative Pain Relief After Laparoscopic Cholecystectomy

Important dates

Study start: 2021
Primary completion: 2021
Study completion: 2021
First posted: Mar 15, 2022
Registry last updated: Mar 15, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed