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OpenTrials
Completed

NCT Number: NCT02573558

Intraoperative Sedation and Postoperative Delirium

Delirium are common after orthopedic surgery in the elderly and are directly associated with loss of independence, reduction in the quality of life and increased mortality. The cause of postoperative delirium still remains unclear and may be multifactorial. The aim of this retrospective study is to examine prevalence of postoperative delirium according to the use of dexmedetomidine or propofol in elderly patients undergoing orthopedic surgery under regional anesthesia.

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Key information

Conditions

Orthopedics

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who underwent orthopedic surgery under regional anesthesia
  • age of 65 years or greater

Exclusion criteria

  • General anesthesia
  • age < 65 years
  • central nervous system disease, including dementia and Parkinson's disease
  • Patients who were not received sedation with propofol or dexmedetomidine during the operation

Treatment and study plan

Dexmedetomidine

Drug

Propofol

Drug

Primary outcomes

  1. delirium

    Time frame: within 7 day postoperatively

Secondary outcomes

  1. Wound infection

    Time frame: within 7 day postoperatively

  2. Pulmonary thromboembolism

    Time frame: within 7 day postoperatively

  3. Hospital stay

    Time frame: through study completion, an average of 7days

Other outcomes

  1. Myocardial ischemia

    Time frame: within 7 day postoperatively

  2. Renal failure

    Time frame: within 7 day postoperatively

  3. Hepatic failure

    Time frame: within 7 day postoperatively

Sponsors and collaborators

Lead sponsor

Seoul National University Bundang Hospital

Other

Registry information

Official study title

Prevalence of Postoperative Delirium According to the Use of Dexmedetomidine or Propofol in Elderly Patients Undergoing Orthopedic Surgery: Retrospective Study

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Oct 12, 2015
Registry last updated
Apr 6, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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