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NCT Number: NCT07211529

Intraoperative Paravertebral Block and Postoperative Complications

This study aims to evaluate the clinical association between intraoperative paravertebral block and the reduction of postoperative complications following thoracic surgery.

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Key information

Conditions

Video-assisted Thoracoscopic Surgery (VATS) Acute Respiratory Distress Syndrome (ARDS) Atelectasis Bronchial Diseases Bronchial Spasm Bronchopleural Fistula Bronchospasm Cardiovascular Diseases Disease Embolism Embolism and Thrombosis Lung Cancer (Diagnosis) Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Pathologic Processes Pathological Conditions, Signs and Symptoms Pleural Diseases Pleural Effusion Due to Another Disorder (Disorder) Pneumothorax Postoperative Complications Pulmonary Atelectasis Pulmonary Embolism Pulmonary Embolism (Diagnosis) Pulmonary Infections Respiration Disorders Respiratory Distress Syndrome Respiratory Failure Without Hypercapnia Respiratory Insufficiency Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Tongji Medical College of HUST: Huazhong University of Science and Technology Tongji Medical College Tongji Hospital

Wuhan, Hubei, 430000, China

Location status: Recruiting

Location contact

Guo jiateng Guo

CONTACT

[email protected]

18737552580

About this study

This study is designed as an observational investigation combining both retrospective and prospective components, focusing on patients undergoing thoracic surgery, primarily pulmonary and mediastinal procedures.

Retrospective analysis: We will collect data from patients across multiple campuses of Tongji Hospital who previously underwent thoracic surgery with intraoperative paravertebral block. These cases will be retrospectively analyzed to explore the association between paravertebral block and the reduction of postoperative complications.

Prospective evaluation: For patients enrolled prospectively, we will collect perioperative biochemical parameters, including MMP3, neutrophils, leukocytes, PCT, CRP, and other relevant regulatory factors. Postoperative outcomes will be assessed by recording cough and pain scores, as well as time to first flatus and defecation at 24 and 48 hours after surgery. In addition, patients will be followed for 30 days to document the incidence of postoperative complications.

Clinical correlation: The association between the measured biomarkers and patient outcomes will be systematically evaluated to determine their clinical relevance in predicting prognosis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female participants aged 18 years or older.
  • Scheduled to undergo thoracic surgery via Video-Assisted Thoracoscopic Surgery (VATS) or Robotic-Assisted Thoracoscopic Surgery (RATS), including wedge resection, segmentectomy, lobectomy, or mediastinal surgery.
  • Signed informed consent obtained prior to study participation. -

Exclusion criteria

  • Patients who refuse to provide informed consent.
  • Anesthesiologists who have not received training in ultrasound-guided paravertebral block (PVB-US).
  • History of ipsilateral thoracic surgery.
  • Conversion to open thoracotomy during the procedure.
  • Patients who did not complete the scheduled surgery due to disease progression or medical reasons.
  • Patients who are lost to follow-up or refuse postoperative follow-up. -

Treatment and study plan

Paravertebral Block (PVB)

Procedure

Participants in this arm will receive a paravertebral nerve block (PVB) performed intraoperatively under ultrasound guidance prior to the thoracic surgical procedure. The block will target the relevant thoracic vertebral levels corresponding to the surgical site. Standard local anesthetic agents will be administered according to institutional protocols. This intervention aims to provide perioperative analgesia, reduce postoperative pain, and potentially decrease the incidence of postoperative complications. All participants will also receive standard intraoperative monitoring and anesthesia management as per routine clinical practice.

Other names: PVB, Paravertebral Analgesia, Paravertebral Injection, Ultrasound-Guided Paravertebral Block (UG-PVB / US-PVB), Thoracic Paravertebral Block (TPVB), Paravertebral Nerve Block

Primary outcomes

  1. Postoperative Complications

    Time frame: 1 to 3 months postoperatively

    Postoperative complications following thoracic surgery will be assessed as the primary outcome. These complications include pulmonary infection, respiratory failure, pleural effusion, atelectasis, bronchospasm, pneumothorax, aspiration-induced lung injury, pulmonary embolism, bronchopleural fistula, and acute respiratory distress syndrome (ARDS). The incidence of these complications will be systematically recorded and analyzed to evaluate the clinical impact of the intervention.

Study contacts

Contact information is provided by the study sponsor or research team.

Guo jiateng Guo

CONTACT

[email protected]

18737552580

Sponsors and collaborators

Lead sponsor

Tongji Hospital

Other

Registry information

Official study title

Perioperative Paravertebral Block Reduces Postoperative Complications in Thoracic Surgery: An Observational Study

Acronym: IPVB and POCs

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
Oct 8, 2025
Registry last updated
Oct 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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