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Completed

NCT Number: NCT04683614

Intraoperative Norepinephrine Versus Fresh Frozen Plasma in Patients Undergoing HIPEC to Reduce Renal Insult

comparing the effect of low dose norepinephrine infusion versus fresh frozen plasma in patients undergoing HIPEC to reduce renal insult

Completed

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Key information

Conditions

Anesthesia

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Walaa Y Elsabeeny

Cairo, 11796, Egypt

About this study

To compare the efficacy of maintaining intraoperative hemodynamic stability through infusing low dose norepinephrine versus fresh frozen plasma in patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy in cancer patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA I and II
  • World Health Performance Status ≤2
  • scheduled for CRS/HIPEC operations

Exclusion criteria

  • patient's refusal
  • allergy to any of the used drugs
  • impaired renal or liver functions

Treatment and study plan

norepinephrine

Drug

5 mic/kg/hr norepinephrine

Other names: low dose norepinephrine

fresh frozen plasma

Biological

early administration of fresh frozen plasma

Other names: Blood products

Primary outcomes

  1. Renal insult

    Time frame: 24 hours

    Creatinine level increase 0.3 mg/dl above preoperative baseline

Sponsors and collaborators

Lead sponsor

National Cancer Institute, Egypt

Other

Registry information

Official study title

Intraoperative Norepinephrine Versus Fresh Frozen Plasma in Patients Undergoing HIPEC to

Important dates

Study start
2020
Primary completion
2022
Study completion
2022
First posted
Dec 24, 2020
Registry last updated
Jun 21, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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