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Completed

NCT Number: NCT05099523

Intraoperative Different Concentrations Oxygen And Oxidatıve Stress Markers

The aim of the study was to assess the effect of intraoperative oxygen (O2), which was applied at 30% and 50% concentrations on patients who had undergone septoplasty surgery, on Total Oxidant Status (TOS), Total Antioxidant Status (TAS), and Oxidative Stress Index (OSI).

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Key information

Conditions

Stress Hyperoxia Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Zonguldak Bülent Ecevit University

Zonguldak, Kozlu, 67600, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients aged between 18-60 years,
  • ASA I-II risk class with a minimum operative time of 1.5 hour(s) for whom septoplasty operation under elective conditions

Exclusion criteria

  • metabolic, endocrine, hepatic, cardiac, or renal diseases,
  • malignancies and who used a drug with antioxidant properties such as vitamin E-C
  • acetylcysteine in the last 48 hours,
  • patients requiring intraoperative 100% O2 inhalation

Treatment and study plan

taking arterial blood sample through the injector

Procedure

taking blood samples from patients applied with different oxygen concentrations

Primary outcomes

  1. EFFECTS OF INTRAOPERATIVE OXYGEN USED AT DIFFERENT CONCENTRATIONS ON OXIDATIVE STRESS MARKERS

    Time frame: end of the surgery

    TAS and TOS values occurring at different oxygen concentrations

Sponsors and collaborators

Lead sponsor

Zonguldak Bulent Ecevit University

Other

Registry information

Official study title

The Effects of Intraoperative Oxygen Used at Different Concentrations on Oxidatıve Stress Markers

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Oct 29, 2021
Registry last updated
Oct 29, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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