Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT07592468

Intraoperative CO₂ (Carbon Dioxide)

To evaluate whether intraoperative fractionated CO₂ laser treatment of surgical wound edges improves postoperative scar appearance compared with untreated wound edges following Mohs micrographic surgery (MMS).

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Age range

18 year–89 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Baylor University Medical Center

Dallas, Texas, 75246, United States

About this study

This is a randomized, split-scar clinical study. After patients undergo the MMS surgery and before the wound is closed one half of the wound edge will be treated with a CO2 laser and the other half will be untreated. The side of the would receiving the laser treatment will be determined by random assignment. The study aims to evaluate if the wound edge that is laser treated will have an improved scar appearance compared to the non-laser treated wound edge.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18-89 years
  • Diagnosis of cutaneous malignancy treated with MMS
  • Surgical defect suitable for primary linear or flap closure with adequate length to permit split-scar design
  • Ability to understand and provide informed consent

Exclusion criteria

  • Pregnancy
  • Inability to provide informed consent
  • Non-English speaking patients
  • History of abnormal wound healing (e.g., keloid disorder)
  • Active infection at the surgical site
  • Immunosuppression felt to significantly impair wound healing
  • Use of isotretinoin within the past 6 months
  • Prior radiation therapy to the surgical site
  • Patients belonging to vulnerable populations including prisoners, children, or individuals unable to consent

Treatment and study plan

CO2 Fractionated Laser

Device

intraoperative fractionated CO₂ laser treatment of surgical wound edges

Non CO2 Laser Treatment

Procedure

Untreated CO2 fractionated laser wound edges

Primary outcomes

  1. Improvement of postoperative scar appearance

    Time frame: 3 months

    To evaluate whether intraoperative fractionated CO₂ laser treatment of surgical wound edges improves postoperative scar appearance compared with untreated wound edges following Mohs micrographic surgery. Evaluating the perspective of the scar from both the patient and medical professional using the Patient and Observer Scar Assessment Scale (POSAS), which evaluates scar quality. Using a scale of 1-10, where 1 is "like normal skin" and 10 is the "worst imaginable and using verbal feedback from patients about the appearance of their scars.

Secondary outcomes

  1. Scar Appearance

    Time frame: 3 months

    To assess patients overall satisfaction with scar appearance. This will be done verbally with patients stating they are "satisfied, somewhat satisfied, or not satisfied".

  2. Physician Scar Assessments

    Time frame: 3 months

    A group of blinded medical professionals will assess the treated and untreated scar using several standardized assessments. The first is the Patient and Observer Scar Assessment Scale (POSAS), which evaluates scar quality. Using a scale of 1-10, where 1 is "like normal skin" and 10 is the "worst imaginable. The second is the Vancouver Scar Scale (VSS). This scale evaluates scars across 4 physical characteristics using a score range of 0-13, where 0 represents normal skin and 13 represents the most severe scarring. Finally the third assessment is the Global Aesthetic Improvement Scale (GAIS). This scale looks at how much better the patient looks compared to pre-surgery. This scale uses a scoring range of 1-5, where 1 represents exceptional improvement and 5 represents worse.

  3. Clinical Safety and Healing Outcomes.

    Time frame: 1 week, 1 month, 3 months

    To evaluate the safety of intraoperative fractionated CO₂ laser treatment, including healing time and complication rates. During the follow up visits the physician will do conduct a visual assessment for presence of any infection, dehiscence, poor wound healing. The physician will use a global assessment of 1-5 and the formal Patient and Observer Scar Assessment Scale (POSAS), which evaluates scar quality. Using a scale of 1-10, where 1 is "like normal skin" and 10 is the "worst imaginable.

Study contacts

Contact information is provided by the study sponsor or research team.

Umer Nadir, MD

CONTACT

[email protected]

214-820-2361

Sponsors and collaborators

Lead sponsor

Baylor Research Institute

Other

Registry information

Official study title

Intraoperative Fractionated CO₂ Laser Treatment of Wound Edges During Mohs Micrographic Surgery

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
May 18, 2026
Registry last updated
May 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.