Skip to main content
OpenTrials
Completed

NCT Number: NCT01304264

Intraocular Pressure, Blood Pressure, Ocular Perfusion and Blood Flow Fluctuations in Glaucoma Patients

To evaluate whether add-on to prostaglandin therapy with twice a day (bid) dorzolamide is statistically superior to twice a day (bid) timolol with regard to increasing ocular blood flow

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Open Angle Glaucoma Eye Diseases Glaucoma Glaucoma, Open-Angle Ocular Hypertension

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Eye Clinic Lithuania Health Science Hospital Kaunas Clinics

Kaunas, 50009, Lithuania

About this study

Hypotensive treatments for glaucomatous optic neuropathy (GON), depending on their chemical composition can influence the ocular circulation independent of intraocular pressure (IOP) reduction. It is therefore important not only to identify ocular blood flow deficits in GON, but also document the influence of GON treatments on the ocular circulation

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Open angle glaucoma subjects receiving prostaglandin monotherapy in both eyes

Exclusion criteria

  • younger than 18 years old
  • women of child bearing potential

Treatment and study plan

Color Doppler Imaging

Device

Color Doppler imaging (CDI) system for measurements of blood flow in the ophthalmic (OA), central retinal (CRA), and nasal (NPCA) and temporal (TPCA) posterior ciliary arteries. In each vessel, peak systolic velocity (PSV) and end diastolic velocity (EDV) were determined, and Pourcelot's resistive index will be calculated (RI = (PSV-EDV)/PSV).

Other names: timololum maleate, dorzolamidum, latanoprostum

Primary outcomes

  1. Ocular Color Doppler Imaging

    Time frame: 8 AM; 8 PM

    Color Doppler Imaging

    • Nasal post ciliary artery (NPCA)
    • Temporal posterior ciliary artery (TPCA)
    • Ophthalmic artery (OA)
    • Central retinal artery (CRA)

Secondary outcomes

  1. IOP, BP, OPP (mean, fluctuations, amplitude)

    Time frame: 8 AM-12AM-4PM-8PM

    IOP, BP, OPP (mean, fluctuations, amplitude) Goldmann applanation tonometry Brachial artery pressure and radial pulse

Sponsors and collaborators

Lead sponsor

Lithuanian University of Health Sciences

Other

Collaborators

  • Indiana University
  • Merck Sharp & Dohme LLC

Registry information

Official study title

Comparison of Intraocular Pressure, Blood Pressure, Ocular Perfusion and Blood Flow Fluctuations During the Addition of Dorzolamid vs Timolol in Glaucoma Subjects Treated With Prostaglandin Analogue Monotherapy

Important dates

Study start
2011
Primary completion
2011
Study completion
2011
First posted
Feb 25, 2011
Registry last updated
Jan 12, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.