Skip to main content
OpenTrials
Completed

NCT Number: NCT07390656

Intradialytic Resistance and Flexibility Exercise in Hemodialysis Patients

This study examined whether different types of exercise performed during hemodialysis sessions affect patients' health and quality of life. Patients receiving regular hemodialysis were assigned to resistance exercise, flexibility exercise, or usual care during dialysis. Changes in health-related outcomes were evaluated before and after the exercise period.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Hemodialysis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Muğla Sıtkı Koçman University Training and Research Hospital

Muğla, 48000, Turkey (Türkiye)

About this study

This single-center pilot study was conducted to explore the effects of exercise performed during hemodialysis on patients' health. Adult patients undergoing maintenance hemodialysis participated in one of three groups: resistance exercise, flexibility exercise, or usual care without exercise. The exercise programs were carried out during routine dialysis sessions under supervision.

Patients' clinical measurements and self-reported health outcomes were assessed at the start of the study and again after completion of the exercise period. The study was carried out between December 2020 and April 2021 following approval by the institutional ethics committee.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 years or older
  • Receiving maintenance hemodialysis for at least 3 months
  • Stable clinical condition
  • Ability to participate in exercise during hemodialysis sessions
  • Provided written informed consent

Exclusion criteria

  • Acute illness or unstable cardiovascular disease
  • Severe musculoskeletal or neurological conditions limiting exercise
  • Recent hospitalization
  • Cognitive impairment preventing cooperation
  • Participation in another structured exercise program

Treatment and study plan

Resistance exercise

Behavioral

A structured resistance exercise program performed during routine hemodialysis sessions under supervision.

Flexibility Exercise

Behavioral

A structured flexibility and stretching exercise program performed during routine hemodialysis sessions under supervision.

Primary outcomes

  1. Change in dialysis adequacy assessed by Kt/V (urea)

    Time frame: From baseline to 12 weeks

    Change in dialysis adequacy measured by single-pool Kt/V (urea).

  2. Change in dialysis adequacy assessed by urea reduction ratio (URR)

    Time frame: From baseline to 12 weeks

    Change in dialysis adequacy measured by urea reduction ratio (URR), expressed as a percentage

Secondary outcomes

  1. Change in Short Form-36 (SF-36) Health-Related Quality of Life score

    Time frame: From baseline to 12 weeks

    Change in health-related quality of life assessed using the Short Form-36 Health Survey (SF-36), a validated 36-item questionnaire.

    SF-36 domain scores range from 0 to 100, with higher scores indicating better health-related quality of life.

  2. Change in Beck Depression Inventory score

    Time frame: From baseline to 12 weeks

    Change in depressive symptoms assessed using the Beck Depression Inventory (BDI). Scores range from 0 to 63, with higher scores indicating more severe depressive symptoms.

  3. Change in body mass index (BMI)

    Time frame: From baseline to 12 weeks

    Change in body mass index (BMI), calculated as weight in kilograms divided by height in meters squared (kg/m^2). Higher BMI indicates greater body mass relative to height.

  4. Change in fat tissue index (FTI)

    Time frame: From baseline to 12 weeks

    Change in fat tissue index (FTI) assessed by bioelectrical impedance analysis (BIA), calculated from fat tissue mass (FTM) normalized to height squared (kg/m^2).

  5. Change in lean tissue index (LTI)

    Time frame: From baseline to 12 weeks

    Change in lean tissue index (LTI) assessed by bioelectrical impedance analysis (BIA), calculated from lean tissue mass normalized to height squared (kg/m^2).

  6. Change in physical function assessed by the 6-minute walk test (6MWT)

    Time frame: From baseline to 12 weeks

    Change in physical function assessed using the 6-minute walk test (6MWT), measured as the total distance walked in meters.

Sponsors and collaborators

Lead sponsor

Dilek GİBYELİ GENEK

Other

Registry information

Official study title

Effects of Intradialytic Resistance and Flexibility Exercises on Clinical Outcomes in Hemodialysis Patients: A Pilot Randomized Controlled Trial

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Feb 5, 2026
Registry last updated
Feb 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.