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Completed

NCT Number: NCT01007838

Intradialytic Progressive Resistance Training for Maintenance Haemodialysis Patients

The purpose of this study is to investigate the effects of a 12 week progressive resistance training during haemodialysis on muscle quantity and physical functioning in chronic kidney disease patients receiving maintenance haemodialysis.

It is hypothesised, based on previous literature involving similar resistance training protocols in other catabolic conditions, that the resistance training will result in a significant increase in muscle quantity as well a physical function.

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Key information

Conditions

Chronic Kidney Disease Atrophy Behavior Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Motor Activity Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathologic Processes Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Signs and Symptoms Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Renal unit, Ysbyty Gwynedd, North West Wales NHS Trust

Bangor, Gwynedd, LL57 2PW, United Kingdom

About this study

Muscle wasting is common in patients with chronic kidney disease and has been associated with decreased ability to complete activities of daily living, increased hospitalisation and therefore and decreased quality of life.

In other catabolic conditions, such as cancer or rheumatoid arthritis, exercise is an established treatment to reverse muscle wasting. It is uncertain whether exercise has this effect in the chronic kidney disease population due to an altered hormone system that may prevent the anabolic effects of exercise from occurring. However, progressive resistance training, which is exercise that is most effective at eliciting an anabolic response has not been effectively carried out with haemodialysis patients.

Therefore, this study aims to investigate whether or not a twelve week intradialytic progressive resistance training programme will have an effect on muscle quantity, physical function and quality of life in patients receiving maintenance haemodialysis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Chronic kidney diseases stage five requiring maintenance hemodialysis.

Exclusion criteria

  • Patients who have been receiving dialysis for less than 3 months;
  • Are under the age of 18years;
  • Have medical contradictions to participate in the exercise programs;
  • Any uncontrolled medical condition which does not allow participation in exercise;
  • Have known neuro-muscular disorders;
  • Have any other uncontrolled medical condition, including pregnancy;
  • Are not independently ambulant for 50 m;
  • Have received anabolic intervention, or had catabolic conditions within the last 3 months;
  • Have a cardiac pacemaker or other unsuitable implanted device for magnetic resonance;
  • Are vulnerable to heat stress;
  • Or are unable to give consent.

Treatment and study plan

Progressive resistance training programme

Other

Progressive resistance training programme using a dialysis specific fitness machine: 80 % of predicted one repetition max, weight lifted will be increased when three sets of ten repetitions can be completed without failure.

Other names: Intradialytic resistance exercise

Sham Exercise

Other

Lower body stretching exercise using the easiest rehabilitation elastic Theraband

Progressive resistance training

Other

Progressive resistance training programme using a dialysis specific fitness machine: 80 % of predicted one repetition max, weight lifted will be increased when three sets of ten repetitions can be completed without failure.

Primary outcomes

  1. Muscle Cross Sectional Area

    Time frame: Change from baseline in cross sectional area at 12 weeks

    Muscle cross sectional area (quadriceps group) taken at midpoint slice between superior aspect of femoral head and the femoral condyle.

Secondary outcomes

  1. Muscle Strength

    Time frame: Change from baseline in muscle strength at 12 weeks

    Bilateral knee extensor isometric strength.

Sponsors and collaborators

Lead sponsor

Bangor University

Other

Collaborators

  • Betsi Cadwaladr University Health Board

Registry information

Official study title

Effects of Progressive Resistance Training During Haemodialysis on Muscle Quantity and Function in Patients With Chronic Kidney Disease

Acronym: PRT

Important dates

Study start
2009
Primary completion
2011
Study completion
2011
First posted
Nov 4, 2009
Registry last updated
Jan 5, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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