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Completed

NCT Number: NCT06137937

Intradialytic Aerobic Exercise in CKD Patient

Intradialytic aerobic exercise is not effective in increasing hemodialysis adequacy but is effective in improving physical performance in twice-weekly hemodialysis patients.

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Key information

Conditions

Chronic Kidney Diseases Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

25 year–54 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Al Ihsan Hospital

Bandung, West Java, Indonesia

About this study

Uremic myopathy occurs in 60-75% of Chronic Kidney Disease (CKD) patients undergoing hemodialysis, which causes a decrease in muscle strength and physical performance. Increasing dialysis adequacy is beneficial in reducing the impact of uremia on muscles. Intradialytic aerobic exercise in thrice-weekly hemodialysis patients has improved dialysis adequacy and physical performance. This study aims to determine the effect of intradialytic aerobic exercise on improving dialysis adequacy and physical performance in twice-weekly hemodialysis patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • End Stage Renal Disease Patient stage 5 with Glomerular Filtration Rate <15mL/minute/1.73m2 aged 25-54 years undergoing hemodialysis two times per week for three months to five years
  • Hemoglobin levels > 8mg/dl
  • Mini-Mental State Examination (MMSE) score of ≥24
  • Hamilton Depression Rating Scale (HDRS) score <25

Exclusion criteria

  • Received aerobic exercise in the last 3 months
  • History of hospitalization in the last 3 months
  • Access for hemodialysis circulation via the femoral vein.
  • IMT <18,5 (underweight) dan ≥35 (obese class II)
  • Non-stable cardiovascular disease, uncontrolled glucose, acute infection disease

Treatment and study plan

Aerobic Exercise

Behavioral

Intradialytic aerobic exercise for eight weeks

Primary outcomes

  1. Kt/V

    Time frame: eight weeks

    Dialysis adequacy (Kt/V) and physical performance test with a Short Physical Performance Battery (SPPB) were evaluated before and after the intervention

Sponsors and collaborators

Lead sponsor

Universitas Padjadjaran

Other

Registry information

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Nov 18, 2023
Registry last updated
Mar 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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