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NCT Number: NCT05290610

Intracranial Stimulation Mapping In Epilepsy

This is a single group prospective study to determine the feasibility for generating brain maps that localize cerebral functions and inter-regional information flow in partial epilepsy in adult patients.

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Key information

Conditions

Epilepsy Brain Diseases Central Nervous System Diseases Nervous System Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Minnesota

Minneapolis, Minnesota, 55455, United States

Location status: Recruiting

Location contact

Alexander Herman, MD, PhD

CONTACT

[email protected]

612-625-1194

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female 18 years and older at screening.
  • Written informed consent is obtained from the participant to comply with the requirements of the study.
  • Stated willingness to comply with all study procedures and availability for the duration of the study
  • Currently undergoing clinically indicated intracranial EEG monitoring for planning of epilepsy surgery in the University of Minnesota/MINCEP program.

Exclusion criteria

  • Pregnancy ruled out prior to approval for intracranial EG monitoring.
  • Persons who are rendered temporarily or permanently invulnerable by inability to understand the research due to study complexity, cognitive impairment, or by inability to make independent decisions owing to University of Minnesota or to Fairview health services.

Treatment and study plan

Functional mapping

Other

Intracranial EEG data acquisition, observation and behavioral testing, and intracranial electrical stimulation

Primary outcomes

  1. The effect of prefrontal direct electrical brain stimulation on cognitive effort

    Time frame: Immediately after stimulation sessions

    The change in subjective value of cognitive effort (area under the curve) after direct electrical brain stimulation to different areas of the prefrontal cortex during an effortful task

Study contacts

Contact information is provided by the study sponsor or research team.

Matthew Maple

CONTACT

[email protected]

612-946-1424

Sponsors and collaborators

Lead sponsor

University of Minnesota

Other

Registry information

Official study title

Intracranial Stimulation Mapping In Epilepsy -The InStim Study

Important dates

Study start
2022
Primary completion
2027
Study completion
2027
First posted
Mar 22, 2022
Registry last updated
Apr 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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