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Completed

NCT Number: NCT06075342

Intracardiac Hemodynamics and Myocardial Strain in Athletes and First Responders

The goal of this observational study is to compare the differences of intracardiac hemodynamics and myocardial strain in athletes with different training levels to adapt to long-term high-level training in rest conditions. The main questions aim to answer are: 1. whether an increase in amplitude and duration of intracardiac hemodynamics and myocardial strain compared with healthy controls; 2. Whether significant correlations exist between the hemodynamic indices and training level.

Participants will be asked to filling out the questionnaire, such as the age, training year (the number of years the athlete has participated in any sport), technical hierarchy (promoted by the Competitive Sports Department of the General Administration of Sport of China, weekly training time in the last 6 months, height, weight, body surface area, heart rate, systolic blood pressure, and diastolic blood pressure; and will be asked to perform an examination of transthoracic echocardiography.

Researchers will compare differences of cardiac structure and function, especially the hemodynamics and myocardial strain to see if training level could affect the cardiac function through hemodynamics and myocardial strain.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chengdu Sport University

Chengdu, Sichuan, 610041, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • athletes and healthy control subjects without regular exercise habits;
  • no specific medical history or chronic illness.

Exclusion criteria

  • A previous history of arterial hypertension, diabetes mellitus, heart, kidney, hepatic, infectious, psychiatric, malignant, disorders, taking drugs that can influence ECG intervals, and electrolyte imbalance;
  • poor echocardiographic image quality and abnormal segmental ventricular wall movement.

Treatment and study plan

Exercise

Behavioral

Exercise intervention according to the training program

Other names: exercise training

Primary outcomes

  1. intracardiac hemodynamics in mmHg/mm using vector flow mapping

    Time frame: through study completion, an average of 1 year

    intraventricular pressure gradient from left ventricular apex to base

  2. myocardial strain in % using two-dimension tissue tracking

    Time frame: through study completion, an average of 1 year

    left ventricular longitudinal strain

Secondary outcomes

  1. wall shear stress in pascal using vector flow mapping

    Time frame: through study completion, an average of 1 year

    segmental wall shear stress of the left ventricle

Sponsors and collaborators

Lead sponsor

Chengdu Sport University

Other

Collaborators

  • Institute of Sports Medicine, General Administration of Sport of China

Registry information

Official study title

Research of Intracardiac Hemodynamics and Myocardial Strains of Athlete's Heart

Acronym: IHMS

Important dates

Study start
2021
Primary completion
2023
Study completion
2024
First posted
Oct 10, 2023
Registry last updated
Jul 30, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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