Intra-procedural Spectral CT for Image-guided Embolization and Ablation in Interventional Oncology

The aims of this study are:

• Demonstrate the feasibility of acquisition and image quality of intra-arterial spectral CT images obtained during mapping arteriography prior to trans arterial radioembolization (TARE) for liver cancer treatment.

• Assess the procedural utility of Spectral CT images as part of the TARE workflow, such as hepatopulmonary shunt fraction estimation, lesion identification, prediction of tumor: normal liver (T:N) dose ratio, and dose distribution
• Investigate the feasibility, safety, and image quality of Spectral CT images obtained during tumor ablation.
• Explore the feasibility of assessing physiologic tissue changes using Spectral CT (effective anatomic number maps)

• During ablation with microwave, cryoablation, and irreversible electroporation in an ex vivo model
• For image-guided tumor ablation, such as lesion identification, probe placement, and ablation monitoring.

Inclusion criteria

• Age > or = 18 years
• Tumor in an area without prior surgical or ablative therapy
• At least 1 tumor greater than 1.5 cm in greatest diameter

Exclusion criteria

• Not eligible for indicated procedure.
• BMI > 35
• Prior surgery.