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NCT Number: NCT06859307

Intra-Abdominal Instillation Of Fresh Frozen Plasma Versus Corticosteroids In Prevention Of Recurrent Attacks Of Adhesive Intestinal Obstruction: A 2 Years' Experience Clinical Study

Adhesive Intestinal obstruction is an inevitable complication of abdominal surgery with significant morbidity associated with poor quality of life and predispose to repeated hospitalization. Most of them (73% - 90%) can be managed conservatively.Despite advances in surgery, 15to 30% require surgical intervention primarily or due to failure of conservative management. Because of the nature of the disease recurrence has been estimated to be 30%.Many attempts to prevent formation of postoperative adhesions have been tried. In this trial, we will study the effect of corticosteroids and FFP in prevention of adhesive small bowel obstruction recurrence for follow up of 2 years duration.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Adhesive Peritoneal Band Cicatrix Fibrosis Pathologic Processes Pathological Conditions, Signs and Symptoms Tissue Adhesions

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Medicine, Zagazig, Sharqia Province, Egypt

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with attacks of adhesive intestinal obstruction

Exclusion criteria

  • Associated abdominal malignancy, patients with adhesive IO who respond to conservative treatment.

Treatment and study plan

intra-abdominal instillation of corticosteroids

Procedure

after adhesiolysis, peritoneal lavage with diluted corticosteroids will be instillated intra-abdominally

intra-abdominal instillation of fresh frozen plasma

Procedure

after adhesiolysis, peritoneal lavage with diluted FFP will be instillated intra-abdominally

Primary outcomes

  1. intestinal obstruction

    Time frame: from 1 day to 2 years post operative

    intestinal obstruction is detected if the patient had constipation and vomiting with ultrasound showing dilated bowel and to and fro movement and the plain erect shows multiple air fluid levels

  2. bowel injury

    Time frame: from 1 day to 2 years post operative

    bowel injury will be detected if intestinal contents present in the drain or wound

  3. wound infection

    Time frame: from 1 day to 2 weeks post-operative

    wound infection is detected if there is pus in the drain or wound

Secondary outcomes

  1. age

    Time frame: from 2 to 3 days before surgery

    age will be recorded in years

  2. sex

    Time frame: from 2 to 3 days before surgery

    The sex of the patient will be recorded (male or female)

Sponsors and collaborators

Lead sponsor

Zagazig University

Other Gov

Registry information

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Mar 5, 2025
Registry last updated
Aug 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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