Intervention on Modifiable Lifestyle Risk Factors for Dementia Prevention

There are encouraging indications from observational and prospective studies that late life multidomain lifestyle interventions can reduce the risk of cognitive decline and dementia, as well as improve cognition. However, these studies raise major issues related to scalability and adherence which can be addressed by relying on technology. These studies mainly used intensive and costly face-to-face interventions that are not easily implemented on a large scale. Furthermore, there are challenges with the adherence to all the components of a multi-domain lifestyle program.

Technology-delivered interventions have the potential to overcome some of the limitations of traditional face-to-face interventions. They confer numerous advantages including scalability of use in a real-world setting while limiting geographical constraints and other logistical challenges such as clinic attendance requirements. Such delivery modes also offer user convenience (e.g., undertaken at home and flexible schedule) and reduced costs associated with large-scale deployment of studies and programs.

In addition to the inclusion of technology, the success of health promotion interventions may also be improved by integrating models of lifestyle habit patterns and behaviour change determinants. The coach-based intervention will integrate behavioural change techniques based on the Behaviour Change Wheel developed by Michie. The coach intervention approach will also be guided by the Transtheoretical model of behaviour change principles proposed by Prochaska and DiClemente, and Motivational Interviewing techniques described by Rollnick and Miller.

The Proof-of-Concept study is a 10-week pre-post within-subject parallel group treatment-only study. There will be three single-domain groups (diet; physical activity or cognitive engagement), and one multidomain group. Participants will receive up to 9 weekly coach-assisted counselling sessions. The goal is to recruit up to 55 participants with at least one of the target risk factors : unhealthy diet, low level of cognitively stimulating activity or physical activity). Participants with a single risk factor will be invited to the single-domain condition for which they have a risk. Participants with multiple risk factors will be invited to the multidomain condition. The risk level for each domain will be examined before and after the intervention to assess whether the intervention has induced a clinically significant change.

Inclusion criteria

• Proficient or native speakers in French;
• Computer literate;
• Committed not to participate in another program related to any of the three intervention domains for the duration of the trial;
• At least one of the following:

• Low cognitive engagement in cognitively stimulating activities, defined as a score ≤ 15 on the CAQ
• Low level of physical activity defined as less than 600 MET-min/week (~150 minutes/week) of MVPA measured using the IPAQ-SF
• Low adherence to the Mediterranean-type diet defined as a score of ≤ 8 on the adapted Canadian MDS

Exclusion criteria

• Presence of a cognitive impairment as measured by the Cogstate Brief BatteryTM ;
• General anesthesia within the last 6 months;
• Participation in any previous validation studies related to the program;
• Participation, currently or within the last 6 months, in a program where they received any of the three interventions;
• Unable to commit participation over the period of the study.
• Participants in the precontemplation stage of change.
• Participants with a high level of perceived stress.
• Having received a diagnosis of:

• Dementia or neurodegenerative disease;
• Past or present neurological disorder;
• Severe psychiatric disorder;
• Uncontrolled cardiovascular or metabolic diseases;
• Alcoholism or drug addiction;
• Any other conditions expected to limit participation.

Domain-Specific exclusion criteria

• Participants will be excluded from the physical activity intervention, but not the trial, if they have a medical contraindication to physical activity based on the Physical Activity Readiness Questionnaire
• Individuals with dietary restrictions due to medical reasons, allergies or severe intolerance or an history of eating disorders will be excluded from participation in the healthy diet intervention.