NCT Number: NCT07219680
The goal of this clinical trial is to learn whether a personalized, multi-component, virtual speech language treatment program can improve communication and quality of life for adults with primary progressive aphasia (PPA) and their primary communication partners. The study will enroll participants who speak English and/or Spanish.
The main questions the study aims to answer are:
* Is the telerehabilitation program feasible and acceptable for people with PPA and their study partners? * Do participants with PPA and study partners find treatment beneficial? * What patterns of treatment response are seen in participants? * Which outcome measures are most useful for evaluating changes in communication and quality of life?
Researchers will compare participants who receive intervention immediately to participants assigned to a waitlist control group (who will receive treatment after a delay) to see whether participation in the treatment program is associated with improvements in communication and quality of life.
Participants will:
* Take part in speech language therapy sessions delivered by video visit that combine restorative, compensatory, and partner-focused communication strategies. Treatment may take place after a waiting period. * Receive education and communication training together with their partner. * Complete speech, language, and cognitive assessments. * Complete questionnaires about communication abilities, daily functioning, and quality of life.
Interested in participating?
Request Info40 year and older
All sexes
Interventional
Not applicable
Austin, Texas, 78712, United States
Location status: Recruiting
Camille Wagner Rodriguez, MS
CONTACT
Carly M Millanski, MS
CONTACT
Maya L Henry, PhD
PRINCIPAL_INVESTIGATOR
Stephanie M Grasso, PhD
PRINCIPAL_INVESTIGATOR
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
for Persons with PPA:
Inclusion criteria
for Care Partners:
The participant and/or study partner must have basic experience using a computer.
Exclusion criteria
for persons with PPA:
In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing names of personally relevant targets in multiple communication modalities. Biweekly (45-90 minute) sessions with a clinician target multimodal communication and the use of strategies to support word retrieval. These skills are also trained via daily independent practice. The participant meets six times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.
Other names: Multi-LRCT
In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Treatment focuses on production of individually-tailored, personally relevant scripts. The participant completes 30 minutes per day of independent practice, during which they speak in unison with a video model. Biweekly (45-90 minute) sessions with a clinician target clear and accurate script production, memorization, and conversational usage, as well as multimodal communication. The participant meets six times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.
Other names: Multi-VISTA
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Percent correctly named trained/untrained pictures
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Percent correct intelligible, scripted words for trained/untrained scripts
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Number of conversation barriers and facilitators observed in conversation
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
A likert-type survey characterizing frequency and type of communication modalities used in conversation, administered to both the person with PPA and their conversation partner.
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
A standardized aphasia assessment.
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
A psychosocial questionnaire for individuals with aphasia. Scores range from 0-84, with higher scores indicating greater impact of aphasia.
Time frame: post-treatment (approximately 12-13 weeks after treatment onset)
A survey characterizing acceptability of and perceived response to treatment.
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
A measure evaluating quality of life for caregivers. Scores range from 0-100, with higher scores indicating greater quality of life.
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
A survey characterizing care partner use of coping strategies.
Contact information is provided by the study sponsor or research team.
Grasso Lab Research Coordinator
CONTACT
Henry Lab Research Coordinator
CONTACT
Maya Henry
Other
Intervention to Promote Communication Quality of Life for Persons With Language-Led Dementia and Their Partners: A Randomized Pilot Trial
Acronym: Multi-PA
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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