Skip to main content
OpenTrials
Completed

NCT Number: NCT02168712

Interval Versus Continuous Training on Functional Capacity and Quality of Life in Patients With Coronary Artery Disease

Exercise therapy increase functional capacity improving the morbidity and mortality of patients with cardiovascular disease. Moderate continuous training is the best established training modality for this patients. However, a body of evidence has begun to emerge demonstrating that high intensity interval training obtained better results in terms of morbidity and mortality.

The purpose of this randomized clinical trial was to determine the effect of two types of exercise training: moderate continuous training vs high interval training on functional capacity and quality of life as well as verify the safety in its application.

We included 72 patients with coronary artery disease by assigning one of the training modality for 8 weeks. We analyzed cyclo-ergo-spirometry data, aspect related to quality of life as well as a record of adverse events.

Completed

Looking for future studies?

Notify Me

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hospital Infanta Elena

Valdemoro, Madrid, 28342, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Coronary heart Disease, with functional class II-III according to New York Heart Association classification system.
  • At least 4 weeks from acute cardiac event, percutaneous or surgery revascularization.
  • Optimized medical treatment in adequate doses ( betablockers, ACE inhibitors, ARA II, statins and antiplatelet drugs)
  • Age > 18 years old.
  • Willing to participate and sign an informed consent form

Exclusion criteria

  • Residual ischemia waiting for revascularization.
  • Any cardiac event for the last 4 weeks
  • Abnormal Ergometry with hemodynamic or clinically significant arrhythmias during the procedure.
  • History of severe ventricular arrhythmia
  • Uncontrolled glycaemia or blood pressure
  • Moderate to severe Chronic Pulmonary Obstructive Disease
  • Osteomuscular and/or mental disorder that hampers an adequate adherence to the intervention program
  • Other vascular diseases: rheumatologic/ autoimmune disorders, thrombopathies, hemophilia.
  • Active oncologic disease.
  • Treatment with corticosteroids.

Treatment and study plan

Moderate continuous exercise training

Other

Interval exercise training

Other

Primary outcomes

  1. Impact on functional capacity

    Time frame: 2 months

    Basal and peak oxygen consumption values will be measured.

Secondary outcomes

  1. quality of life

    Time frame: 2 months

    Quality of life will be compared between the two arms with one generic questionnaire (SF-36) and one ischemic heart disease specific questionnaire (MacNew)

Other outcomes

  1. Incidence of Adverse Events

    Time frame: 2 months

    The incidence of cardiovascular adverse events in each group will be compared

Sponsors and collaborators

Lead sponsor

Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz

Other

Registry information

Official study title

Interval Versus Continuous Exercise Training on Functional Capacity and Quality of Life in Patients With Coronary Artery Disease: a Randomized Clinical Trial

Important dates

Study start
2011
Primary completion
2014
Study completion
2014
First posted
Jun 20, 2014
Registry last updated
Jun 20, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.