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OpenTrials
Completed

NCT Number: NCT02498730

Interval Training in Bipolar Disorder

Our main objective will be to evaluate the chronic effects (12 weeks) of high-intensity interval training compared to moderate intensity (same total work) on reducing the symptoms of bipolar disorder, cortical changes, as well as on the VO2max. In addition, the investigators will establish what influence of gain to VO2max has on reducing symptoms.

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Key information

Age range

18 year–59 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Institute of Psychiatry (IPUB)

Rio de Janeiro, Brazil

About this study

Physical exercise has significant effects on health promotion and the consequent reduction of the severity of bipolar disorder (BD). This review establishes a pattern of response of exercise and potential impact on the pathophysiology of BD; , as well as, produces hypotheses on how acute and chronic effect of exercises may act differently; and provides future perspectives with the focus of the exercise as an important and innovative model of treatment for BD and mental disorder. A critical evaluation of the literature was undertaken including the influence of exercise on health promotion in patients with mental disorders, neurochemical behavior exercise-induced, as well as reflective introduction of news perspectives of training control in severe exercise domain. The exercise induces significant changes in monoaminergic after, and with long-term training, and work with a threshold of exercise can modulate positive effects on mood. Fast adaptive effects from the high intensity interval training should be considered in BD patients. However, there must be caution in his administration. We speculate that exercise may be a way of maintaining euthymia in the case of BD, making it less vulnerable patient to stay longer at a time of neutrality. Future research is needed to adopt a training strategy that is both time efficient in the different areas and adequate for the population in question.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Bipolar Criteria (DSM-IV),
  • sedentary lifestyle

Exclusion criteria

  • 60 and over,
  • Cardiovascular Disease,
  • Panic disorder,
  • Metabolic syndrome Diagnosis

Treatment and study plan

Interval Training

Behavioral

High Intensity Interval Training at 100% VO2Max

Other names: High intensity interval training, HIIT, HIT

Continuous training

Behavioral

Continuous Stimulous at 60% VO2Max

Other names: Moderate Training, Endurance

Control

Behavioral

Only Dependent Variables Measures

Other names: No Intervention

Primary outcomes

  1. Symptom Scales (Hamilton and Young)

    Time frame: 0 week, 6 week, 12 week

    Variable Measured to reduction of symptoms

Secondary outcomes

  1. Cortical Changes (EEG) - Loreta

    Time frame: 0 week, 6 week, 12 week

    Measured to evaluate changes due to training

  2. VO2Max

    Time frame: 0 week, 6 week, 12 week

    Variable Measured to assess cardiovascular improvement

  3. Cognitive Function

    Time frame: 0 week, 6 week, 12 week

    Executive Function, Time Reaction, Atention, and Memory

Sponsors and collaborators

Lead sponsor

Universidade Federal do Rio de Janeiro

Other

Registry information

Official study title

Can the High Intensity Interval Training (HIIT) Deliver Superior and Rapid Decrease of Symptoms of Bipolar Disorder? a Controlled and Randomized Study

Acronym: HIIT

Important dates

Study start
2015
Primary completion
2017
Study completion
2017
First posted
Jul 15, 2015
Registry last updated
Jul 29, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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