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OpenTrials
Completed

NCT Number: NCT00418652

Interruption of Dorsal Visual Stream Using TMS

Trans Cranial Magnetic Stimulation (TMS) over dorsal visual system will disturb the ability to identify objects with decreased level of fragmentation

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Key information

Conditions

Healthy

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Psychiatry Clinic - Sheba Medical Center

Tel Litwinsky, 52621, Israel

About this study

The participants performed two tasks under three different TMS conditions: no TMS, 10Hz TMS for over the dorsal stream (PO3 EEG site) or over the vertex.

First they performed a perceptual closure task which asked them to identify an object in a series of six progressively less degraded pictures.

Then, they also performed a control task previously shown not to be mediated by the LOC and not to be impaired in schizophrenia: The perception of illusory contours.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Normal controls

Exclusion criteria

  • neurological, ophthalmological or psychiatric problems
  • family history of schizophrenia
  • left handed

Treatment and study plan

No TMS intervention

Device

In the "no TMS" condition, no simulation was given and no coil placed near participants' heads.

TMS over the PO3 EEG site

Device

10Hz TMS over the dorsal stream (PO3 EEG site)

Other names: MAGSTIM biphasic stimulator

TMS over the vertex

Device

10Hz TMS for over vertex.

Other names: MAGSTIM biphasic stimulator

Primary outcomes

  1. Results of the study assignments performed by the participants during the study.

    Time frame: The participants performed the tasks once during their study visit

    The subjects performed 2 tasks:

    The primary dependent measures consisted of the level of detail needed for correct object identification, response accuracy, and response time in milliseconds for correct responses.

    Illusory Contour Task: Subjects also performed a pulsed pedestal task, Participants were shown 55 drawings for 500 ms each. Some drawings contained partial contours which defined a geometric shape, while in others the contours did not define a shape. Participants were asked to indicate whether they recognized a geometric shape or not. Accuracy and response time were measured.

Sponsors and collaborators

Lead sponsor

Sheba Medical Center

Other Gov

Registry information

Official study title

Interruption of Dorsal Visual Stream Using TMS in Normal Controls

Important dates

Study start
2006
Primary completion
2010
First posted
Jan 5, 2007
Registry last updated
Aug 4, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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