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Completed

NCT Number: NCT02018848

Internet-delivered Attention Training for Obsessive-Compulsive Disorder

The goal of this study is to investigate an attention training program for participants with Obsessive-Compulsive Disorder. The attention training consists of a modified dot probe task with picture stimuli related to washing and checking paired with neutral pictures.

Participants are randomly assigned to an experimental and a placebo-control group. After a minimum of 4 weeks of attention training we expect to find differences between participants of the experimental and the control group in terms of attention bias, OCD symptoms, anxiety and depression.

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Key information

Conditions

Obsessive-Compulsive Disorder Anxiety Disorders Mental Disorders

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Humboldt-Universität zu Berlin

Berlin, State of Berlin, 10099, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosis of primary OCD according to OCI-R self report (cut-off >=18)

Exclusion criteria

  • suicidal
  • substance abuse or addiction
  • psychotic symptoms
  • visual impairment if not compensated with optical aid

Current treatment is not an exclusion criterion, but data on treatment status (current psycho- or pharmacotherapy for OCD) will enter our statistical analyses.

Treatment and study plan

Attention Training Program

Behavioral

Other names: ATP, Attention Bias Modification Treatment, ABMT, Bias Modification, Attentional Training

Primary outcomes

  1. Yale-Brown Obsessive-Compulsive Scale Self-Report Scale (Y-BOCS-SRS) T1

    Time frame: pre-treatment, estimated: between day 1 and day 7 after enrolment (no time limit set)

    The Y-BOCS-SRS measures severity of OCD symptoms.

  2. Yale-Brown Obsessive-Compulsive Scale Self-Report Scale (Y-BOCS-SRS) T2

    Time frame: post-treatment, between day 1 and 6 after T2 Bias Assessment (time limit set)

    The Y-BOCS-SRS measures severity of OCD symptoms.

  3. Yale-Brown Obsessive-Compulsive Scale Self-Report Scale (Y-BOCS-SRS) T3

    Time frame: follow-up, between day 27 and 50 after T2 questionnaires (time limit set)

    The Y-BOCS-SRS measures severity of OCD symptoms.

Secondary outcomes

  1. Obsessive-Compulsive Inventory-Revised (OCI-R) T1

    Time frame: pre-treatment, estimated: between day 1 and day 7 after enrolment (no time limit set)

    The OCI-R measures severity of OCD symptoms.

  2. Obsessive-Compulsive Inventory-Revised (OCI-R) T2

    Time frame: post-treatment, between day 1 and 6 after T2 Bias Assessment (time limit set)

    The OCI-R measures severity of OCD symptoms.

  3. Obsessive-Compulsive Inventory-Revised (OCI-R) T3

    Time frame: follow-up, between day 27 and 50 after T2 questionnaires (time limit set)

    The OCI-R measures severity of OCD symptoms.

Other outcomes

  1. Beck Anxiety Inventory (BAI) T1

    Time frame: pre-treatment, estimated: between day 1 and day 7 after enrolment (no time limit set, all further steps relative to exact time point of T1 questionnaires)

    The BAI measures severity of anxiety symptoms.

  2. Beck Anxiety Inventory (BAI) T2

    Time frame: post-treatment, between day 1 and 6 after T2 Bias Assessment (time limit set)

    The BAI measures severity of anxiety symptoms.

  3. Beck Anxiety Inventory (BAI) T3

    Time frame: follow-up, between day 27 and 50 after T2 questionnaires (time limit set)

    The BAI measures severity of anxiety symptoms.

  4. Beck Depression Inventory II (BDI-II) T1

    Time frame: pre-treatment, estimated: between day 1 and day 7 after enrolment (no time limit set, all further steps relative to exact time point of T1 questionnaires)

    The BDI measures severity of depressive symptoms.

  5. Beck Depression Inventory II (BDI-II) T2

    Time frame: post-treatment, between day 1 and 6 after T2 Bias Assessment (time limit set)

    The BDI measures severity of depressive symptoms.

  6. Beck Depression Inventory II (BDI-II) T3

    Time frame: follow-up, between day 27 and 50 after T2 questionnaires (time limit set)

    The BDI measures severity of depressive symptoms.

  7. Attention bias towards OCD-relevant stimuli at T1 measured with a dot-probe task.

    Time frame: after T1 questionnaires and pre-treatment, estimated: between day 1 and 3 after T1 questionnaires (no time limit set)

    Attention bias is measured using a dot-probe task. In this task pairs of pictures (OCD-relevant/neutral) are presented briefly on a computer screen. Next, a probe randomly appears on one of the two former picture locations. Participants have to react to that probe by pressing the corresponding button on the keyboard.

    Attention bias is calculated as the mean difference in reaction times between trials in which the probe appears at the OCD-relevant location vs. trials in which it appears at the neutral location. The bias assessment session is masked as first training sessions in both groups.

  8. Attention bias towards OCD-relevant stimuli at T2 measured with a dot-probe task.

    Time frame: post-treatment, after a minimum of 8 training sessions over a time of 4 weeks, estimated: between day 1 and 4 after last training session (no time limit set)

    Attention bias is measured using a dot-probe task. In this task pairs of pictures (OCD-relevant/neutral) are presented briefly on a computer screen. Next, a probe randomly appears on one of the two former picture locations. Participants have to react to that probe by pressing the corresponding button on the keyboard.

    Attention bias is calculated as the mean difference in reaction times between trials in which the probe appears at the OCD-relevant location vs. trials in which it appears at the neutral location.

Sponsors and collaborators

Lead sponsor

Humboldt-Universität zu Berlin

Other

Registry information

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Dec 23, 2013
Registry last updated
Nov 13, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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