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NCT Number: NCT07360223

Internalized Symptoms in Adolescents With Autism Spectrum Disorder (ASD) and Typically Developing Adolescents : Gaining Insight Into Coping Strategies and the Psychological Processes Involved

Introduction: Adolescents with autism spectrum disorder (ASD) have more mental health problems than typically developping adolescents (without ASD). Coping strategies are a key concern for adolescents with ASD in managing depressive and anxiety symptoms. Currently, few studies have examined the coping strategies used by adolescents with ASD. The methodological considerations underscore the need for an assessment method tailored to adolescents with ASD. Finally, although current data are still limited, the results suggest that there may be differences between the coping strategies used by adolescents with ASD and typically developing adolescents, thus calling for more in-depth comparative research.

Objectives: This study aims to validate a coping strategies assessment method adapted for adolescents with ASD (1) and to examine coping strategies associated with internalizing symptoms (2)

Population: 252 participants: 84 adolescents with ASD (1), 84 adolescents with autistic traits but no clinical diagnosis of ASD (2), and 84 typically developing adolescents (3). The age range is 12-17 years.

Study design: The study is divided into two parts: a cross-sectional part (T) and a longitudinal part (L).

* The cross-sectional part will include three meetings spread over a period of approximately three months (approximately one meeting per month). * The longitudinal part will consist of a meeting scheduled one year after the last meeting of the cross-sectional part.

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Key information

Age range

12 year–17 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 12-17 years
  • speak french fluently

Exclusion criteria

  • Intellectual disability

Treatment and study plan

Questionnaire and interview

Behavioral

Participants will complete questionnaires and take part in a semi-structured interview

Primary outcomes

  1. Coping strategies

    Time frame: Throughout the entire study, approximately during 5 years

    Measure by questionnaire and semi-structured interviews. Questionnaire : Coping Strategies Inventory (CSI) The questionnaire is designed to identify coping strategy profiles. It includes 8 sub-strategies (Problem solving, Cognitive restructuring, Express Emotions, Social Support, Problem avoidance, Wishful thinking, Self-Criticism, Social Withdrawal) and does not have strict minimum or maximum scores. Instead, it provides an overview of the relative use of each coping strategy

Secondary outcomes

  1. Anxious, depressive and somatic symptoms

    Time frame: Throughout the entire study, approximately during 5 years

    Measure by questionnaire Questionnaire : Revised Children's Anxiety and Depression Scale (RCADS) T-score < 65 → Non-clinical range. Symptoms are minimal or within the typical range compared to the normative population. No clinical concern is indicated T-score ≥ 65 → Borderline/clinically elevated Symptoms are higher than average and may indicate potential anxiety or depression issues.

    T-score ≥ 70 → Clinically significant range Symptoms are substantially elevated compared to peers. There is a high likelihood of clinically meaningful anxiety or depression

Study contacts

Contact information is provided by the study sponsor or research team.

Héloïse HL Louvegny, PhD Student

CONTACT

[email protected]

010 47 80 60 ext. 0471 55 84 10

Stéphanie SM Mazzone, Postdoctoral

CONTACT

[email protected]

02 764 20 34

Sponsors and collaborators

Lead sponsor

Université Catholique de Louvain

Other

Registry information

Important dates

Study start
2026
Primary completion
2031
Study completion
2031
First posted
Jan 22, 2026
Registry last updated
Jan 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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