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NCT Number: NCT05513911

Intermittent Hypoxia and Upper Extremity EMG Recordings in Individuals With Spinal Cord Injury

In this current study, the examiners examine some of the mechanisms of how Acute Intermittent Hypoxia (AIH) effects the upper extremity of survivors of spinal cord injury. This is accomplished both with the use of a load cell to determine elbow strength changes and high density grid electromyography (EMG) to record bicep muscle activations before and after bouts of AIH

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Key information

Conditions

Spinal Cord Injuries Central Nervous System Diseases Nervous System Diseases Spinal Cord Diseases Trauma, Nervous System Wounds and Injuries

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Shirley Ryan AbilityLab

Chicago, Illinois, 60611, United States

About this study

It has been shown previously that there is an increase in strength in survivors of spinal cord injury after brief bouts of Acute Intermittent Hypoxia. In this study, participants are fitted with a high density EMG electrode on the biceps brachii, and attached to a load cell at the wrist, they are asked to flex and extend their elbow at various levels of intensity. This is performed before and after the 30 minute session of AIH. The investigators hope to identify specific types of motor units of the upper extremity of survivors of spinal cord injury after AIH to help further our understanding of what mechanisms may be causing the known increase in muscle strength post AIH

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • History of Spinal Cord Injury from C3-T4
  • Non-progressive spinal cord injury
  • More than 6 months since initial Spinal Cord injury
  • Ability to understand and willingness to sign written informed consent

Exclusion criteria

  • Presence of any of the following medical conditions: Congestive heart failure, arrhythmia, uncontrolled high blood pressure, uncontrolled diabetes mellitus, COPD/emphysema and severe asthma
  • Persons with known coronary artery disease, a history of myocardial infarction, or known carotid or intracerebral artery stenosis
  • Medical clearance will be required if participant is taking any other investigational agents
  • Women who are pregnant or nursing
  • Individuals with tracheostomy
  • Cannot pursue other research studies which may interfere
  • Unable to consent
  • Individuals who are not yet adults (infants, children, teenagers)
  • Prisoners

Treatment and study plan

Acute Intermittent Hypoxia

Other

Acute Intermittent Hypoxia is administered in 30-60 second bouts of 9% O2 concentration, followed by 60-90 seconds of normoxic air concentrations (21% O2, room air). This procedure is repeated 15 times for a 30 minute session

Other names: AIH

Primary outcomes

  1. Maximal Elbow Strength [Newtons]

    Time frame: 30 minutes Post intervention

    Recordings of the elbow joint torque are taken while the participant is asked to flex and extend the elbow voluntarily at a maximum level of intensity

Secondary outcomes

  1. Biceps Brachii Muscle activation [μv]

    Time frame: 30 minutes post intervention

    Peak electromyographic activation of the biceps brachii muscle during maximum voluntary flexion and extension tasks

Sponsors and collaborators

Lead sponsor

Shirley Ryan AbilityLab

Other

Registry information

Official study title

Intermittent Hypoxia and Upper Limb Training in Individuals With Spinal Cord Injury

Important dates

Study start
2016
Primary completion
2016
Study completion
2019
First posted
Aug 24, 2022
Registry last updated
Aug 24, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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