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OpenTrials
Completed

NCT Number: NCT03746158

Interindividual Variation in Excretion of Curcumin

The objective of this project is to elucidate the interindividual variations in excretion of curcumin and its metabolites.

Completed

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Key information

Conditions

Metabolites Gut Microbiota

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Institute for Applied Life Sciences

Amherst, Massachusetts, 01003, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-30 year old healthy adults

Exclusion criteria

  • Exclusion criteria included those who are <18 or >30 years old, have a BMI of <20 or >29 kg/m2, have a weight change >4.5 kg in the past 3 months, exceed exercise activities of a curcumin level over the past 3 months, have any diseases, especially intestinal disorders, had abnormal liver or kidney function tests. Those who smoke, consume more than two alcoholic drinks per day, use medication affecting gut microbiota profile (e.g., antibiotics and probiotics) in past three months will also be excluded.
  • Additionally, this study excludes menopausal women, those using hormone-based contraceptives, those with abnormal menstrual cycles, and those who are pregnant, lactating or planning to become pregnant.

Treatment and study plan

Curcumin

Dietary Supplement

subjects will be assigned to consume one capsule of curcumin (330 mg of curcumin per capsule) three times a day (one capsule with each meal).

Primary outcomes

  1. Determine the concentration of curcumin and its metabolites in the human fecal samples.

    Time frame: 3-4 weeks

    Utilize LC-MSMS to identify and quantify the curcumin and its metabolites in the subjects fecal samples.

Sponsors and collaborators

Lead sponsor

University of Massachusetts, Amherst

Other

Registry information

Official study title

University of Massachusetts Amherst

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Nov 19, 2018
Registry last updated
Dec 17, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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