Interest of the Nefopam and PCA Morphine Combination for Postoperative Analgesia in Patients Undergoing Colon Surgery

This study analyses interest of iv nefopam in combination with paracetamol after major abdominal surgery because the effect of morphine-sparing is discussed when combined these agents.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Colonic Neoplasms Colonic Diseases Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Diverticulosis, Colonic Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU de Nîmes

Nîmes, Gard, 30029, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult patient with a score ASA between I and III
Patient scheduled for elective major abdominal surgery (by laparotomy) for cancer or diverticulosis
Patient that signed the consent form

Exclusion criteria

- Patient treated in emergency situation
Patient with chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis)
Patient that needs a surgery for restoration of continuity
Patient pregnant, breastfeeding, or during periods of genital activity using no contraception.
Patient with contraindications to nefopam, morphine, or paracetamol
Patient with chronic obstructive pulmonary disease, renal or severe hepatic impairment
Patient under analgesics treatment
Patient who participated in a clinical study in the previous 6 months.

Treatment and study plan

Nefopam

Drug

The nefopam group received 120 mg nefopam (Acupan, Pharmbio, France) by continuous iv infusion over the study period (48h)

Saline solution

Other

The Control group received 120 mg placebo infusion (saline solution) by continuous iv infusion over the study period (48h).

Primary outcomes

Estimate morphine consumption

Time frame: over 48 hours

mg

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nīmes

Other

Registry information

Acronym: NEFOPAM

Important dates

Study start: 2007
Primary completion: 2007
Study completion: 2007
First posted: Aug 8, 2018
Registry last updated: Jun 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed