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Completed

NCT Number: NCT02097784

Interest of the Echocardiography in the Management of Cirrhotic Patients With Acute Kidney Injury

This prospective study focuses on the interest of the echocardiography for cirrhotic patients, who present acute kidney injury corresponding to the criteria of hepatorenal syndrome. This echocardiography will be done before the volemic expansion and the final diagnostic of hepatorenal syndrome or prerenal azotemia. The primary endpoint is to describe the hemodynamic characteristics of this population at the time of acute kidney injury and their association with diagnostic of hepatorenal syndrome or prerenal azotemia. Patients with elevated filling pressure, predicting poor outcome of volemic expansion will be excluded of the study after the echocardiography and will not undergo volemic expansion but appropriate management.

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Key information

Conditions

Cirrhosis Acute Kidney Injury Diastolic Function Digestive System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Fibrosis Hepatorenal Syndrome Kidney Diseases Liver Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hospices Civils de Lyon - Hôpital de la Croix-Rousse

Lyon, 69004, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients > 18 years
  • written consent for the participation of the study
  • cirrhosis with portal hypertension and ascite
  • acute kidney injury according to AKIN criteria (rapid increase of creatinine (48 hours) > 26.4 µmol or > 50% comparing with baseline). Baseline creatinine is the last value of creatinine before admission or creatinine at the admission if stable during 5 days.
  • absence of argument for acute tubular necrosis or other organic acute renal injury
  • absence of argument for shock

Exclusion criteria

  • pregnant women
  • volemic expansion before echocardiography
  • portal thrombosis
  • presence of TIPSS
  • history of cardiac or renal pathology
  • atrial fibrillation
  • cardiac valvulopathy
  • technical limitation due to echogenicity

Treatment and study plan

Echocardiography

Procedure

Primary outcomes

  1. Hemodynamic features assessed by echocardiography before the volemic expansion of cirrhotic patients with acute renal injury corresponding to the criteria of hepatorenal syndrome.

    Time frame: At Day0 : at the time of diagnostic of acute kidney injury, before volemic expansion.

    Systolic and diastolic function assessment, filling pressures, pulmonary arterial hypertension

Secondary outcomes

  1. Tolerance of volemic expansion, as recommended by international guidelines

    Time frame: After 48 hours of volemic expansion

    Clinical tolerance of volemic expansion, acute pulmonary oedema

  2. Response to vasoconstrictor treatment of hepatorenal syndrome, in case of diagnostic of hepatorenal syndrome

    Time frame: 1 month after inclusion

    Renal function recovery, renal replacement therapy, liver transplantation

  3. Mortality

    Time frame: 1 month after inclusion

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Acronym: CIRREN

Important dates

Study start
2014
Primary completion
2018
Study completion
2018
First posted
Mar 27, 2014
Registry last updated
Dec 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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