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NCT Number: NCT06202222

Interest of Intensive Postoperative Rehabilitation Following Minimally Invasive Lung Resection

For patients diagnosed with non-small cell lung cancer (NSCLC), lung resection surgery remains the gold standard for curative treatment. This scheduled operation is associated with significant morbidity, particularly in individuals with impaired cardio-respiratory function. Therefore, patient optimization is paramount. The process begins prior to surgery with preoperative rehabilitation, commonly referred to as "prehabilitation," serving as the foundation for various Enhanced Recovery After Surgery programs. The training methods employed in these programs bear similarity to rehabilitation programs designed for patients with chronic obstructive pulmonary disease (COPD).

Postoperatively, patients undergoing thoracic surgery partake in daily physiotherapy sessions, aiming to optimize the postoperative period, minimize the respiratory impact of surgery, and reduce the length of hospital stay. However, this treatment is not currently standardized and primarily involves early mobilization, including walking, and respiratory physiotherapy. Our focus is on the intensity and methods of this postoperative rehabilitation.

There is limited literature on effective early rehabilitation in the immediate postoperative period, and existing studies suggest no adverse events associated with postoperative training. Therefore, our objective is to assess whether combining endurance training with standard physiotherapy (walking and respiratory physiotherapy) enhances the functional capacity of individuals undergoing lung surgery.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Valenciennes, Hospital, Valenciennes, Hauts-de-France, France

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients requiring surgery for diagnosed or undergoing diagnosis of lung cancer.
  • Patients in need of major lung resection through a minimally invasive approach.
  • Patients capable of performing the chair rise test.

Exclusion criteria

  • Contraindications to cyclo-ergometry: Deep vein thrombosis in a lower limb. Patients with one or both lower limbs amputated. Rheumatological pathology, trauma, or previous surgery in the lower limb, pelvis, or spine, resulting in limited joint amplitude or strict immobilization.

Dermatological conditions with severe lesions preventing prolonged sitting on a bicycle.

  • Glasgow score less than 15.
  • Patients who have not undergone pulmonary resection by minimally invasive surgery.
  • Patients hospitalized outside the thoracic surgery department before the first post-operative visit with the physiotherapist on Day 0.

Treatment and study plan

rehabilitation

Other

The patient undergoes a daily session on the cycloergometer (Am3i Ergometer). The patient is instructed to pedal at a heart rate ranging from 60% to 80% of their maximum heart rate (calculated as 220 minus their age) for a duration of 20 minutes. These sessions can be conducted with oxygen therapy for patients dependent on oxygen. The sessions are maintained until the patient is discharged from the department.

Primary outcomes

  1. Number of chair lifts at the scheduled visit 30 days after surgery

    Time frame: 30 days after surgery

    number of chair lifts

Secondary outcomes

  1. number of days between surgery and discharge patient

    Time frame: 30 days after surgery

  2. chair rise test

    Time frame: 7 days after surgery

  3. number of complication GRADE II of clavien dindo classification

    Time frame: 30 days after surgery

Study contacts

Contact information is provided by the study sponsor or research team.

Fairuz BOUJIBAR, PhD

CONTACT

[email protected]

+33 2 32 88 89 90 ext. 65593

Jean-Marc BASTE, PhD

CONTACT

[email protected]

+33 2 32 88 87 04

Sponsors and collaborators

Lead sponsor

University Hospital, Rouen

Other

Registry information

Official study title

Interest of Intensive Postoperative Rehabilitation Following Minimally Invasive Lung Resection: A Randomized Controlled Study

Acronym: IRPOL

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
Jan 11, 2024
Registry last updated
Sep 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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