Interaction Study of Clopidogrel 300/75 mg Given Alone or Concomitantly With Pantoprazole 80 mg in Healthy Subjects

The total study duration per subjects is 8 - 9 weeks broken down as follows:

• Screening: 2 to 21 days before the first dosing
• Period clopidogrel/placebo: 7 days including 5 days treatment
• Period clopidogrel/placebo + pantoprazole: 14 days including 12 days treatment
• Washout between periods: at least 14 days after last dosing with respect to clopidogrel treatment
• End of study: 7 to 10 days after the last dosing

Inclusion criteria

Healthy male subject:

• as determined by medical history, physical examination including vital signs and clinical laboratory tests:
• with a body weight between 50 kg and 95 kg and with a Body Mass Index (BMI) between 18 and 30 kg/m²

Exclusion criteria

• Evidence of inherited disorder of coagulation/hemostasis functions
• Smoking more than 5 cigarettes or equivalent per day
• Abnormal hemostasis screen
• Unability to abstain from intake of any drug affecting hemostasis throughout the whole study duration
• Any contraindication to clopidogrel and/or pantoprazole

The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.