Interaction of Potassium and Genetic Risk Variants on Diabetes Risk

The investigators propose to study the association of the KCNJ11 (Potassium Voltage-Gated Channel Subfamily J Member 11) polymorphisms on diabetes risk in the Atherosclerosis Risk in Communities (ARIC) and Jackson Heart Study (JHS) cohorts. The investigators also propose to test for an interaction between serum K and these genetic variants. By testing for such an interaction, it will be determined if, among participants with these genetic variants, a low-normal serum K was a stronger predictor of diabetes risk compared to those participants without these genetic variants.

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Key information

Conditions

Diabetes Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Member of the Atherosclerosis Risk in Communities (ARIC) Study or Jackson Heart Study (JHS) cohorts

Exclusion criteria

Had not fasted 8 or more hours for the baseline visit
Prevalent diabetes at baseline exam
Missing information on serum potassium
Missing single nucleotide polymorphism (SNP) data
Evidence of kidney dysfunction
Race other than black/African American or white/Caucasian
Missing other covariates

Treatment and study plan

Primary outcomes

Associations of serum potassium and KCNJ11 variants with incident diabetes as represented by odds ratio

Time frame: through study completion, mean of 8 years of follow-up

Calculation of odds ratio will be used to represent the risk of incident diabetes associated with serum K, rs5215, and rs5219 within the cohort

Sponsors and collaborators

Lead sponsor

Duke University

Other

Collaborators

Johns Hopkins University
University of Colorado, Denver
University of Mississippi Medical Center

Registry information

Official study title

Interaction of Potassium Measures With Potassium Channel Genetic Variants on Diabetes Risk: The Atherosclerosis Risk in Communities (ARIC) Study and Jackson Heart Study (JHS)

Important dates

Study start: 2015
Primary completion: 2017
Study completion: 2017
First posted: Dec 8, 2017
Registry last updated: Dec 8, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed