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Completed

NCT Number: NCT00631514

Interaction Between Antihypertensives and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

NSAIDs may increase blood pressure and blunt the effects of many antihypertensives. Members of these drug classes differ in their propensity to such an interaction.

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Key information

Conditions

Hypertension Cardiovascular Diseases Vascular Diseases

Age range

55 year–78 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Split University School of Medicine. Family Practice Department

Split, 21000, Croatia

About this study

To compare prospectively the effects of piroxicam, ibuprofen and acetaminophen on blood pressure control in hypertensive patients with osteoarthritis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Treated hypertensives of either gender aged between 55 and 76 years
  • About 50% with concomitant osteoarthritis of the hip or knee

Exclusion criteria

  • Normotensive persons or untreated hypertensives
  • Individuals outside the age limits
  • General exclusion criteria (e.g. uncooperative persons, advanced malignancies, participants in other studies)

Treatment and study plan

Acetaminophen

Drug

acetaminophen 1000 mg t.i.d. per os ibuprofen 400-600 mg t.i.d. per os piroxicam 10-20 mg o.d. per os

Other names: paracetamol

Ibuprofen

Drug

acetaminophen 1000 mg t.i.d. per os ibuprofen 400-600 mg t.i.d. per os piroxicam 10-20 mg o.d. per os

piroxicam

Drug

acetaminophen 1000 mg t.i.d. per os ibuprofen 400-600 mg t.i.d. per os piroxicam 10-20 mg o.d. per os

Primary outcomes

  1. Arterial blood pressure

    Time frame: 3 months (3 individual blocks of 1 month each)

Secondary outcomes

  1. Body weight,serum electrolytes, urinary electrolytes (Na, K)

    Time frame: 3 months (3 periods of 1 month)

Sponsors and collaborators

Lead sponsor

University of Split

Other

Collaborators

  • Dr Ivancica Pavlicevic Family Practice Office

Registry information

Official study title

Relevance of the Interaction Between Antihypertensive and Antirheumatic Drugs in a Family Practice

Important dates

Study start
2005
Primary completion
2006
Study completion
2006
First posted
Mar 7, 2008
Registry last updated
Mar 10, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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