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NCT Number: NCT06410183

Inter-rater Reliability of Preoperative Mortality Risk Calculators

The goal of this study is to investigate the inter-rater variability of mortality risk calculations for high-risk non-cardiac surgical patients. For this purpose patient information from health care files were used. Five anesthesiologists calculated the mortality risks with three calculators for 34 high-risk non-cardiac surgical patients. The patients were discussed in a preoperative multidisciplinary discussion in a large teaching hospital in The Netherlands.

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Key information

Conditions

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Rijnstate Hospital

Arnhem, Gelderland, 6800 TA, Netherlands

About this study

Identifying high-risk patients for perioperative treatment and decision-making remains a challenge due to difficulty in reliably estimating morbidity and mortality risks. Assessing surgical risk helps allocating resources, obtaining informed consent, and making shared decisions with a multidisciplinary team (MDT). Multimorbidity is increasing globally in an ageing population with a growing burden of chronic diseases. It has been shown that high-risk non-cardiac surgical patients suffer disproportionally from perioperative complications. Preoperative mortality risk calculators are available and may help to identify high-risk non-cardiac surgical patients already before surgery, triggering efforts to lower the burden of possible complications, e.g., by extended monitoring or specified treatments. A systematic review suggested a significant risk of bias in developing current preoperative risk calculators due to lack of external validation, highlighting the need for enhanced performance and reliability to ensure their effectiveness in clinical practice. Low reliability and performance may, despite their general availability, be why that preoperative risk calculators are not yet consistently used in clinical practice. For daily clinical use, good predictive performance, low inter rater variability and user friendliness are essential. Discrepancies in predictor measurements can cause miscalibration, changes in discriminatory ability, and overall accuracy, leading to clinically relevant variability in risk calculator results. Previous studies have shown that physicians must trust a mortality risk calculator before utilization. High-risk patients suffer especially from complications, and it has been shown that the complications often result in death perioperatively. Therefore, adequate preoperative calculation of mortality risks and early recognition of high-risk non-cardiac surgical patients could benefit from reliable preoperative risk calculation. These high-risk patients can then be discussed in a preoperative multidisciplinary discussion to lower complications and perioperative deaths.

The current study evaluated the inter-rater reliability of calculating preoperative mortality risk scores for high-risk non-cardiac surgical patients in clinical practice among five anesthesiologists. The hypothesis was that the available risk calculators would show moderate to good reliability. For this purpose, five anesthesiologists used the following three risk calculators: the preoperative score to predict postoperative morbidity [POSPOM, the American College of Surgeons surgical risk calculator, and the surgical outcome risk tool [SORT].

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients discussed in a preoperative multidisciplinary team (MDT) meeting.

Exclusion criteria

  • No complete patient file to calculate the mortality risks

Treatment and study plan

No intervention

Other

no intervention

Primary outcomes

  1. inter-rater reliability of three risk calculators: POSPOM, SRC and SORT

    Time frame: After calculation of the mortality risks (1 month)

    Five anesthesiologists calculated mortality risks retrospectively for 34 patients. The intra-class correlation coefficient (ICC) was calculated per risk calculator

Secondary outcomes

  1. mortality risk calculations or 34 patients

    Time frame: 1 month

    the Preoperative scale of postoperative outcome: (POSPOM), the surgical risk calculator: (SRC) and the surgical outcome risk tool: (SORT) mortality risk calculators were used for (retrospective) 30-day mortality risk calculation of 34 patients

Sponsors and collaborators

Lead sponsor

Rijnstate Hospital

Other

Collaborators

  • Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)
  • Utrecht University

Registry information

Official study title

Inter-rater Reliability of Preoperative Mortality Risk Calculators Used for High-risk Noncardiac Surgical Patients

Important dates

Study start
2019
Primary completion
2021
Study completion
2021
First posted
May 13, 2024
Registry last updated
Jun 12, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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