University of California, Los Angeles
Los Angeles, California, 90095, United States
Location status: Recruiting
NCT Number: NCT07177261
The goal of this clinical trial is to investigate for the first time in people with schizophrenia a neural mechanism that is thought to facilitate the formation of social connections - inter-brain synchrony - in order to improve scientific understanding of the neural mechanisms of social dysfunction in the disorder, and to provide a basis for the development of new and better treatments to improve social functioning and connectedness in the illness. The main questions it aims to answer are:
1. Investigate inter-brain synchrony as a neural mechanism of social connection in schizophrenia 2. Manipulate social closeness and test for effects on inter-brain synchrony across groups
The investigators will compare results from people with schizophrenia to a healthy comparison group (controls) who do not have psychotic disorders to see if inter-brain synchrony is greater in controls. Investigators will also compare measures of inter-brain synchrony before and after the social closeness manipulation to see if inter-brain synchrony changes with increasing closeness.
Participants will:
* Have a clinicial diagnostic interview and be assessed for clinical symptoms * Have an EEG recorded while interacting with another person. Participants will first work with the other person to draw a figure, and then tap fingers together. Participants will then either undergo the experimental manipulation to increase social closeness (called, "fast friends") or undergo the control condition that does not increase social closeness (called "small talk"). Participants will then repeat the drawing and finger tapping assessment. * After completing the experimental or control condition, participants will then repeat the procedure with the other condition that was not yet done. * Be interviewed on the number and quality of social interactions.
Interested in participating?
Request Info18 year–65 year
All sexes
Interventional
Not applicable
Los Angeles, California, 90095, United States
Location status: Recruiting
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Participants will interact with another person while both have their EEG recorded. They will ask and answer 12 questions with the other person that become increasingly personal in nature, e.g., "When did you last cry in front of another person? By yourself?"
Participants will interact with another person while both have their EEG recorded. They will ask and answer 12 impersonal questions with the other person , e.g., "Do you prefer digital watches and clocks or the kind with hands? Why?"
Time frame: Interbrain synchrony will be measured immediately before and immediately following the procedure.
Circular correlations for 8-10Hz activity across electrodes and dyads
Time frame: Measured at the start of the study only
Measures of social and family social connections. Participants will be interviewed about the number of social and family connections they have, and if these contacts also know others identified by the participant. These connections will be analyzed with graph network analyses to determine the size and quality of social connections.
Time frame: Investigators will measure these during each of the two maniuplations (small talk and fast friends).
Investigators will video record interactions between dyads (including voice, body, face) and measure behavioral measures of synchrony
Contact information is provided by the study sponsor or research team.
University of California, Los Angeles
Other
Inter-Brain Synchrony as a Neural Mechanism of Social Connection in Schizophrenia
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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