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NCT Number: NCT07072442

Integrative Chinese and Western Medicine for Knee Osteoarthritis

This study aims to investigate if an integrated approach combining Traditional Chinese and Western medicine can better treat knee osteoarthritis. The goal is to see if this combined therapy can more effectively reduce pain severity and frequency, leading to an improved quality of life for KOA patients. Additionally, the study will explore the underlying mechanisms of pain and anti-inflammation related to KOA.

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Key information

Conditions

Knee Osteoarthristis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female aged above 18 years old
  • Kellgren-lawrence grading scale ≥ II
  • Numerical rating scale (NRS) ≥ 4

Exclusion criteria

  • History of bone tumor
  • Pregnancy
  • History of bilateral knee replacement
  • Active infection

Treatment and study plan

Western medicine

Drug

Western medicine treatment only

herbal medicine and acupuncture

Procedure

Western medicine combined acupuncture and herbal medicine treatemnt

Herbal medicine

Drug

Western medicine combined herbal medicine

Acupuncture

Procedure

western medicine combined acupuncture

Primary outcomes

  1. WOMAC

    Time frame: From enrollment to 3 months after treatment completion.

    Western Ontario and McMaster Universities Osteoarthritis (WOMAC) subscale

  2. NRS

    Time frame: From enrollment to 3 months after treatment completion.

    Numerical rating scale (NRS) score for pain

  3. Lequesne's index

    Time frame: From enrollment to 3 months after treatment completion.

    Lequesne's index

Sponsors and collaborators

Lead sponsor

Chang Gung Memorial Hospital

Other

Registry information

Official study title

Integrative Chinese and Western Medicine for Knee Osteoarthritis: Model of Patient Centered Healthcare and Shared Decision-making

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
Jul 18, 2025
Registry last updated
Jul 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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