Integration of Neurocognitive Biomarkers Into a Neuro-Oncology Clinic

Primary outcomes

1. Change in Learning and memory (Neurocognitive Decline)

   Time frame: Baseline, 2, 4, 6, 12, 18, 24 months

   Learning and memory will be assessed by the number of correct responses (the total number of words correctly recalled). The "Verbal Recall" test will be used to measure the number of correct responses over 3 trials, the "Verbal Revision" will be used to measure the number of total correct responses, and the "Verbal Recognition" test will be used to measure number of correct responses minus the incorrect responses. Change is calculated as baseline score subtracted from post-baseline score over time.

2. Change in Attention and Speed of Processing (Neurocognitive Decline)

   Time frame: Baseline, 2, 4, 6, 12, 18, 24 months

   This will be measured by the "Symbols Matching" test. Subjects will be asked to match symbols and corresponding numbers during 90 seconds. The score will be calculated by totaling the number of correct answers during the allotted time. A higher score indicates better functioning.

3. Change in Verbal Fluency (Neurocognitive Decline)

   Time frame: Baseline, 2, 4, 6, 12, 18, 24 months

   This will be measured by the "Words That Start With" test. The total number of words correctly generated (no numbers, no proper names) by the subject will be recorded to generate their score. A higher score indicates better functioning.

4. Change in Fine motor and speed (Neurocognitive Decline)

   Time frame: Baseline, 2, 4, 6, 12, 18, 24 months

   This will be measured by the "Numbers Ordering" test. This test assesses visual scanning and motor tracking requiring focused attention. Subjects are required to sequentially connect numbered dots in ascending order that are randomly scattered on the screen in consecutive order. The total time in seconds to complete the array will be recorded as the score result. A lower score indicates better functioning.

5. Change in Executive functions (Neurocognitive Decline).

   Time frame: Baseline, 2, 4, 6, 12, 18, 24 months

   This will be measured by "Numbers and Letters Ordering" test. This test includes a divided attention component requiring mental flexibility (i.e., executive function). On this subtest, dots with numbers and letters are randomly scattered. Subjects are required to alternate between connecting numbers and letters in an ascending sequential order. Subjects will order numbers and letters from 1 to 13 and from A to M by tapping them as fast as possible in consecutive and alternating order. The total time in whole seconds to complete the array will be recorded. A lower score indicates better functioning.