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NCT Number: NCT06931509

Integration and Interactions Between Visual and Proprioceptive Feedbacks

Mental imagery is a rehabilitation technique for stroke patients, involving the mental representation of movement. Recent technical advancements have enabled the use of visual, proprioceptive, and mixed feedback to enhance motor stimulation. Currently, all post-stroke patients receive these techniques indiscriminately. This study aims to demonstrate differences in the integration of visual and proprioceptive feedback in stroke patients and understand the determinants based on the affected brain area.

Patients with motor disabilities will perform motor imagery tasks with various feedback types while their cortical activity is recorded using EEG. EEG data for each type of feedback will be correlated with the lesion area in order to better understand the ongoing mechanisms.

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Key information

Conditions

Hemiparetic Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Stroke Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU Saint-Etienne

Saint-Etienne, France, 42055

Location status: Recruiting

Location contact

Ahmed ADHAM, Md

SUB_INVESTIGATOR

Diana Rimaud, doctor of science

CONTACT

[email protected]

0477120467 ext. 33

Pascal Giraux, Md

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Hemiplegic subjects : Male or female, aged 18 to 80 years, first ischemic or hemorrhagic stroke, having signed the written consent and affiliated or entitled to a social security scheme

Exclusion criteria

  • Severe cognitive impairment, severe Aphasia or severe neglect that impair ability to understand instructions or to execute tasks

Treatment and study plan

Computerized mirror therapy (IVS3) + Tendon vibration (Vibramoov)

Device

Visit 1 : Followed by 30 movements of Paretic arm wrist extension with 4 randomized experimental conditions (Vision alone, Vibration alone, Vision + Vibration, No feedback), with EEG monitoring. Measurement of movement perception feeling for each condition.

Visit 2 : 30 movements of Paretic arm wrist extension with 4 randomized experimental conditions (Vision alone, Vibration alone, Vision + Vibration, No feedback), with EEG monitoring. Measurement of movement perception feeling for each condition.

Primary outcomes

  1. EEG beta desynchronization

    Time frame: Day 1

    Differences in the EEG beta desynchronization over motor-cortex across the types of feedbacks.

Secondary outcomes

  1. Alpha Band

    Time frame: Day 1

    Alpha Band desynchronization over motor cortex

  2. Occipital alpha band

    Time frame: Day 1

    Occipital alpha band modulations

  3. Beta rebound

    Time frame: Day 1

    Beta rebound (Event related synchronization)

  4. Parietal beta-band

    Time frame: Day 1

    Parietal beta-band desynchronization

  5. Perception of movements

    Time frame: Day 1

    The intensity of the perception of movements using a visual analogue scale and the objective measurement of perceived movement angle reproduced by the healthy hand's and Visual analogic scale

Study contacts

Contact information is provided by the study sponsor or research team.

Diana Rimaud, doctor of science

CONTACT

[email protected]

0477120467 ext. 33

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Saint Etienne

Other

Registry information

Official study title

Study of the Integration and Interactions Between Visual and Proprioceptive Feedbacks in Hemiplegic Patients

Acronym: OptiVis

Important dates

Study start
2025
Primary completion
2028
Study completion
2029
First posted
Apr 17, 2025
Registry last updated
Jul 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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