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NCT Number: NCT07331519

Integrating Smoking Cessation With Low-dose CT-screening for Lung Cancer

The study investigates effectiveness of different smoking cessation methods and low-dose CT based lung cancer screening

Recruiting

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Key information

Conditions

Smoking Cessation Behavior Health Behavior Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

50 year–74 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Helsinki University Hospital, Helsinki, Finland

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About this study

The study population consists of individuals aged 50-74 years with a significant smoking history who continue to smoke. The study design is a prospective and participants are randomized into three study arms: low-dose CT (LDCT) + smoking cessation with a smartphone application (arm 1), LDCT + smoking cessation with written materials (arm 2), smoking cessation with a smartphone application without LDCT (arm 3). The study compares effectiveness of smoking cessation methods, LDCT in lung cancer screening, lung cancer stage distribution, and lung cancer specific survival.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Able to provide written informed consent
  • Age between 50-74
  • Smoked ≥ 15 cigarettes/day for ≥ 25 years or smoked ≥ 10 cigarettes/day for ≥ 30 years and are active smokers (smoking during the last two weeks)
  • Access to a smartphone (iPhone or Android)

Exclusion criteria

  • Current or past melanoma, lung, renal or breast cancer
  • A chest CT examination less than one year before inclusion
  • Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial
  • No access to a smartphone (iPhone or Android)
  • Participant is unwilling or unable to comply with treatment and trial instructions
  • Any condition that study investigators consider an impediment to safe trial participation

Treatment and study plan

Smartphone Application

Other

Suunta smartphone application for smoking cessation

low-dose computed tomography

Other

Low-dose computed tomography based screening for lung cancer

Written materials for smoking cessation

Other

Written materials for smoking cessation

Primary outcomes

  1. Rate of smoking cessation

    Time frame: three months

    The percentage of participants who have quitted smoking between the study arms 1 vs. 2

Secondary outcomes

  1. Rate of smoking cessation

    Time frame: Three months

    The percentage of participants who have quitted smoking between all the study arms

  2. Rate of smoking cessation

    Time frame: 12 and 24 months

    The percentage of participants who have quitted smoking between all the study arms

  3. Rate of long-term smoking cessation

    Time frame: 12 and 24 moths

    The percentage of participants who have had abstinence of smoking for at least six months

  4. LDCT findings

    Time frame: baseline and 24 months

    The percentage of LDCT negative, indetermined, and positive findings by screening round

  5. Sensitivity and specificity of LDCT screening examination

    Time frame: 24 months, 36 months, and 10 years

    Sensitivity and specificity of LDCT screening examination for lung cancer detection (arms 1&2 vs. 3)

  6. Lung cancer incidence

    Time frame: 24 months, 36 months, and 10 years

    Lung cancer incidence (stage specific) (arms 1&2 vs. 3)

  7. Frequency of self-reported smoking cessation verified with CO measurement

    Time frame: 24 months

    Frequency of self-reported smoking cessation verified with CO measurement

Study contacts

Contact information is provided by the study sponsor or research team.

Jussi P Koivunen, MD, PhD

CONTACT

[email protected]

+358504182666

Sanna Iivanainen, MD, PhD

CONTACT

[email protected]

+358504178347

Sponsors and collaborators

Lead sponsor

Oulu University Hospital

Other

Collaborators

  • Finnish Cancer Society

Registry information

Official study title

Integrating Smoking Cessation With Low-dose CT-screening for Lung Cancer - a Randomized Study

Acronym: ISC-LDCT

Important dates

Study start
2026
Primary completion
2026
Study completion
2036
First posted
Jan 12, 2026
Registry last updated
Feb 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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