Integrated Whole-Genome Analysis of Hematologic Disorders

We will use new technologies to look at the DNA, RNA, proteins, and metabolites in the disease-containing blood, bone marrow, or tissue and normal cells from the skin. Our goal is to analyze all of the genes in the diseased and normal skin sample. By comparing the results of the diseased sample and normal skin cells and the results of the two types of genetic information (DNA and RNA), we should be able to identify genetic changes that are important for the initiation, progression, or treatment response of that particular disorder.

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Key information

Conditions

Hematologic Diseases Hemic and Lymphatic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Stanford University School of Medicine

Stanford, California, 94305, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

18 years of age or older
Patient meets the clinical and/or pathologic criteria for the hematologic disorder being examined.
Patient is willing to provide a skin biopsy and five 10 mL tubes of peripheral blood.

Exclusion criteria

Less than 18 years of age
Patient is not willing to provide a skin biopsy and five 10 mL tubes of peripheral blood.

Treatment and study plan

Blood draw

Procedure

skin biopsy

Procedure

Primary outcomes

to identify mutations, changes in DNA copy number, structural rearrangements, or altered coding and non-coding RNA expression

Time frame: sample collection at time of routine visit

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Official study title

Integrated Whole-Genome Analysis of Hematologic Disorders Using High-Throughput Sequencing and Array Technologies

Important dates

Study start: 2009
Primary completion: 2013
Study completion: 2013
First posted: Apr 21, 2010
Registry last updated: May 31, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed