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Completed

NCT Number: NCT00447733

Integrated Treatment to Persons With Mental Disorders and Co-occurring Substance Use Disorders

The purpose of this study is to determine whether Integrated Treatment is effective in the treatment of anxiety and/or depression with co-occurring substance use disorders.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Patients with mental disorders and co-occuring substance use disorders are characterized by high suicide rates, high treatment drop-out rates and long-lasting interpersonal, work, school, health and legal problems. Because mental disorders and substance use disorders co-exist and interact, it may be important to provide a treatment that addresses the substance misuse and mental health problems in an integrated and comprehensive way. Additionally, the health services for patients with mental health and substance use disorders are usually provided by different services and health professionals that rarely cooperate or have qualifications on both kinds of disorders. This also calls for an integration of the services on an organizational level. This approach of integrating services and treatment approaches for both diseases in a comprehensive way is called Integrated Treatment. Several studies have shown that Integrated Treatment is effective in treating the comorbidity of severe mental illness and substance use disorders. The over-all aim of this study is to evaluate the effects of evidence-based Integrated Treatment in anxiety and/or depression with co-occurring substance use disorders. The effects of the treatment will be assesses on changes in substance use and psychopathology.

Comparison: patients receiving treatment-as-usual or non-manualized treatment at general mental health outpatients clinics.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • clinical diagnosis of substance use disorder
  • clinical diagnosis of anxiety disorders
  • clinical diagnosis of nonpsychotic mood disorders
  • written consent
  • planning to live in the catchment area during the treatment

Exclusion criteria

  • schizophrenia spectrum disorders
  • other psychotic disorders
  • mental retardation
  • nicotine abuse/dependency only
  • prescription drug abuse/dependency only
  • planning to move out of the catchment area during the study
  • not able to read or write Norwegian

Treatment and study plan

Integrated mental health and substance use treatment

Behavioral

Psychosocial and drug treatment targeting both the substance use disorder and the psychiatric disorder in an integrated and comprehensive way.

Other names: dual disorder treatment, co-occurring disorders

Treatment as Usual

Behavioral

Non-standardized psychiatric outpatient treatment

Other names: TAU, non-manualized

Primary outcomes

  1. The Symptom Check List 90 (SCL90-r), The Alcohol Use Disorder Identification Test (AUDIT), The Drug Use Disorder Identification Test (DUDIT).

    Time frame: Change during 6 and 12 months follow-up

    We use the SCL-90r to measure symptoms in regard to anxiety, depression and the General Severity Index.

    We use the AUDIT and the DUDIT to measure changes in the use of alcohol and illegal drugs respectively.

Secondary outcomes

  1. The Addiction Severity Index (Europ ASI)

    Time frame: Change during 6 and 12 months follow up

    The Addiction Severity Index (Europ ASI) is used to assess changes in the use of alcohol and illegal substances during the course of the trial.

Sponsors and collaborators

Lead sponsor

University of Oslo

Other

Collaborators

  • SINTEF Health Research

Registry information

Official study title

Effects of Integrated Treatment to Persons With Mental Disorders and Co-occurring Substance Use Disorders

Acronym: ROP

Important dates

Study start
2007
Primary completion
2010
Study completion
2010
First posted
Mar 15, 2007
Registry last updated
Mar 26, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.