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NCT Number: NCT07445243

Integrated Chinese and Western Therapy for Cancer-Related Fatigue

Cancer-related fatigue (CRF) is a common and debilitating symptom in patients with cancer. Evidence-based non-pharmacological approaches include sleep hygiene, physical activity, nutritional management, and traditional Chinese medicine (TCM). This study evaluates the clinical effectiveness of an interdisciplinary holistic program integrating Chinese and Western therapies for CRF among hospitalized cancer patients receiving integrated care. Approximately 100 participants will be enrolled and followed for up to 3 months.

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Key information

Conditions

Cancer-related Fatigue Behavior Health Behavior Neoplasms Neoplasms (Cancer / Tumors) Sleep Hygiene

Age range

20 year–95 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Taichung Tzu Chi Hospital

Taichung, 42743, Taiwan

About this study

Eligible hospitalized cancer patients receiving integrated Chinese and Western care will be enrolled after providing informed consent. Participants will complete a CRF questionnaire and receive a non-invasive holistic integrative care program, including patient education, sleep hygiene, exercise guidance, nutritional assessment/intervention, and TCM-related care. The primary endpoint is change in CRF score. Secondary endpoints include TCM constitution assessment, vital signs, anthropometrics, complete blood count, and liver/renal function tests. Participants will be followed for 3 months from enrollment.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Inclusion Criteria:

Signed informed consent form.

Age 20 to 95 years.

Receiving integrated Chinese and Western holistic care.

Agree to provide clinically relevant data for this study.

Exclusion criteria

Refuse to continue participation during the study period, or the family requests discontinuation (withdrawal).

Psychiatric disorder that makes the participant unable to cooperate.

Exclusion criteria

-

Treatment and study plan

Integrated Chinese and Western Holistic Care Program

Other

An interdisciplinary integrative care program combining Western supportive care and Traditional Chinese Medicine to manage cancer-related fatigue in hospitalized oncology patients. Core components include fatigue assessment, patient education and symptom management guidance, sleep hygiene, exercise encouragement, aromatherapy and/or massage, nutrition assessment and counseling, and shared decision-making. Traditional Chinese Medicine consultation may provide acupuncture and/or Chinese herbal medicine according to patient needs and clinical judgment.

Primary outcomes

  1. Change in Cancer-Related Fatigue (CRF) Score (0-10)

    Time frame: From admission (baseline) through discharge (last in-hospital assessment; up to 30 days)

    CRF is assessed using the Taiwan Society of Cancer Palliative Medicine fatigue scale (0-10) during hospitalization. Peak CRF score is defined as the maximum recorded CRF score from admission to discharge. Discharge CRF score is defined as the last in-hospital CRF assessment prior to discharge. The primary outcome is the within-participant change in CRF score from peak to discharge.

Secondary outcomes

  1. Proportion of Participants With Moderate-to-Profound CRF at Discharge (CRF Score ≥4)

    Time frame: At discharge (last in-hospital assessment; up to 30 days after admission)

    Percentage of participants whose discharge CRF score is ≥4 (moderate or above) on the Taiwan Society of Cancer Palliative Medicine fatigue scale (0-10).

  2. Distribution of CRF Severity Categories at Discharge (0, 1-3, 4-6, 7-8, 9-10)

    Time frame: At discharge (last in-hospital assessment; up to 30 days after admission)

    Distribution of discharge CRF scores categorized as 0, 1-3, 4-6, 7-8, and 9-10 on the Taiwan Society of Cancer Palliative Medicine fatigue scale.

Sponsors and collaborators

Lead sponsor

Taichung Tzu Chi Hospital

Other

Registry information

Official study title

Clinical Effectiveness Assessment of Integrated Chinese and Western Therapy for Cancer-Related Fatigue

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Mar 3, 2026
Registry last updated
Mar 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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