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OpenTrials
Completed

NCT Number: NCT00329615

Insulin Treatment in Cancer Cachexia

The study is designed to evaluate whether daily insulin treatment to weight losing cancer patients attenuates progression of cancer cachexia and improves metabolism.

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Key information

Conditions

Cancer Cachexia

Age range

25 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Department of Surgery, Inst of Clinical Sciences

Gothenburg, SE413 45, Sweden

About this study

Randomized study with long-term follow-up based on survival, health related quality of life, food intake, resting energy expenditure, body composition, exercise capacity and measurement of metabolic efficiency.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Weight loss
  • Systemic solid cancer

Exclusion criteria

  • Diabetes
  • Brain metastases
  • Expectant survival of less than 6 months
  • Serum creatinine above 200 umol/l
  • Persistent of recurrent fever
  • Cholestasis

Treatment and study plan

Insulatard, flexpen

Drug

Primary outcomes

  1. Health related quality of life,

  2. food intake,

  3. resting energy expenditure,

  4. body composition,

  5. metabolic efficiency,

  6. spontaneous physical activity,

  7. blood and hormonal tests

  8. serum tumor markers

Secondary outcomes

  1. Survival

Sponsors and collaborators

Lead sponsor

Göteborg University

Other

Collaborators

  • Medical Research Council
  • Swedish Cancer Foundation

Registry information

Official study title

Insulin Treatment in Cancer Cachexia: Effects on Survival, Metabolism and Physical Functioning. A Randomized Prospective Study.

Important dates

Study start
2000
Study completion
2005
First posted
May 25, 2006
Registry last updated
Aug 21, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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