Insulin Sensitivity of the Human CNS System: fMRI Study With Intranasal Insulin Application

The purpose of the study is to investigate whether insulin sensitivity and insulin resistance of the human brain is comparable in all insulin sensitive parts of the brain and whether correlates to other phenotypic information (i.e. whole body insulin sensitivity, BMI, age) of the study participants.

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Key information

Conditions

Obesity Body Weight Diabetes Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Tuebingen

Tübingen, 72074, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Normal routine blood works
for women: negative pregnancy test
healthy

Exclusion criteria

Type 2 diabetes
pregnancy
acute or chronic diseases
Pacemakers
Artificial heart valves
Metal prostheses
Implanted magnetic metal parts (screws, ...)
Metal fragments
Braces
insulin pumps
Tattoos
claustrophobia
reduced temperature sensation and / or increased sensitivity to warming of the body
Ear disease or an increased sensitivity to loud noises

Treatment and study plan

human insulin

Drug

160 U of insulin

Placebo

Drug

Insulin dilution medium without insulin

Primary outcomes

Insulin effect on regional brain activity assessed by fMRI

Time frame: Change from Baseline to 15 minutes and 60 minutes post spray application

Sponsors and collaborators

Lead sponsor

University Hospital Tuebingen

Other

Registry information

Official study title

Insulinsensitivität Des Menschlichen Zentralnervensystems: Kernspintomographische Untersuchung Mit Intranasaler Gabe Von Insulin

Important dates

Study start: 2013
Primary completion: 2014
Study completion: 2014
First posted: Feb 22, 2013
Registry last updated: Dec 3, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed