Insulin- and Glucose Metabolism in Pulmonary Arterial Hypertension

Insulin resistance is a key mechanism in metabolic disorders, which has also been implicated in the development of pulmonary hypertension. In this pilot study, the investigators´ goal is to directly determine insulin sensitivity in idiopathic pulmonary arterial hypertension patients and to compare the results with data from healthy controls.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Insulin Resistance Glucose Metabolism Disorders Hyperinsulinism Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Medical University Graz, Division of Pulmonology

Graz, Styria, 8010, Austria

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

signed informed consent form
patients with idiopathic or hereditary pulmonary hypertension / healthy controls

Exclusion criteria

premenopausal women
other relevant lung disease
relevant left heart disease
untreated systemic hypertension
Diabetes mellitus
pulmonary hypertension other than idiopathic or hereditary form

Treatment and study plan

Primary outcomes

Insulin resistance

Time frame: 1 day

Determination of insulin sensitivity using hyperinsulinemic-euglycemic clamp technique

Sponsors and collaborators

Lead sponsor

Medical University of Graz

Other

Registry information

Official study title

Insulin- and Glucose Metabolism in Pulmonary Arterial Hypertension - a Pilot Study

Important dates

Study start: 2017
Primary completion: 2019
Study completion: 2019
First posted: Jul 12, 2018
Registry last updated: Jan 27, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed