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OpenTrials
Completed

NCT Number: NCT07710209

Instrument-Assisted Soft Tissue Mobilization as an Adjunct to Therapeutic Exercises in Individuals With Knee Osteoarthritis

To determine the efficacy of IASTM as an adjunct to therapeutic exercises on pain, range of motion, and functional performance in individuals with knee OA.

Completed

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Key information

Age range

40 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

FMRL

Karachi, Sindh, Pakistan

About this study

Background: Knee osteoarthritis (OA) is a leading cause of chronic pain and functional limitation, particularly in older adults, and is associated with soft tissue restrictions, quadriceps weakness, and reduced joint mobility. Therapeutic exercise remains a cornerstone of conservative management, but persistent myofascial restrictions may limit its full benefit. Instrument-Assisted Soft Tissue Mobilization (IASTM) has been proposed as an adjunct technique to address fascial adhesions, improve tissue extensibility, and enhance the outcomes of exercise-based rehabilitation. However, evidence regarding its added value when combined with conventional therapeutic exercise in knee OA remains limited.

Objective: To determine the efficacy of IASTM as an adjunct to therapeutic exercises on pain, range of motion, and functional performance in individuals with knee OA.

Methodology: A parallel-group randomized controlled trial was conducted on 50 participants diagnosed with knee OA (Kellgren-Lawrence grade II-III), randomly allocated into two equal groups (n=25 each) using a computer-generated random sequence with allocation concealment. Group A received IASTM combined with a standardized therapeutic exercise protocol, while Group B received the therapeutic exercise protocol alone. Treatment was administered three times per week for 6 weeks. Outcome measures included the Numeric Pain Rating Scale (NPRS), Knee range of motion (goniometry), and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for functional status, assessed at baseline and post-intervention (6 weeks). Data were analyzed using paired and independent sample t-tests, with significance set at p<0.05.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Osteoarthritis, both gender, Age between 40-60 years. -

Exclusion criteria

Not meeting the inclusion criteria, underwent recent surgery of lower limb.

-

Treatment and study plan

IATSM

Behavioral

IATSM were administered for a duration of 6 weeks

Therapeutic Exercise

Behavioral

Therapeutic Exercise were administered for a duration of 6 weeks

Primary outcomes

  1. Numeric Pain Rating Scale (NPRS)

    Time frame: 6 weeks

    The value were taken at base line and after 6 weeks of intervention

  2. Knee range of motion (goniometry)

    Time frame: 6 weeks

    The value were taken at base line and after 6 weeks of intervention

  3. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

    Time frame: 6 weeks

    The value were taken at base line and after 6 weeks of intervention

Sponsors and collaborators

Lead sponsor

Foundation of Medical Research and Laboratories, Pakistan

Other

Registry information

Official study title

Efficacy of Instrument-Assisted Soft Tissue Mobilization as an Adjunct to Therapeutic Exercises in Individuals With Knee Osteoarthritis: A Parallel-Group Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jul 17, 2026
Registry last updated
Jul 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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