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OpenTrials
Completed

NCT Number: NCT01986374

Injection of Hormone to Enhance Implantation in Embryo Transfer After IVF

The endometrium is deprived of signals form the embryo in IVF conditions. Studies suggest that placing HCG into the uterus prior to embryo transfer can enhance implantation.

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

21 year–47 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Servy Massey Fertility Insititute

Atlanta, Georgia, 30327, United States

About this study

The study is in pilot phase, uncontrolled. The risks appear to be minimal and there are conflicting new reports being announced.

A small amount of fluid with HCG is injected into the uterus. HCG is a potent signal to the uterus for preparation for implantation.

This is not a funded study. Three published studies suggest the approach is valid; one refutes the concept.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • infertility patients undergoing IVF with good expectation of two embryos day 3 or day 5. must speak and read English. Includes donor eggs.

Exclusion criteria

abnormal uterus

-

Treatment and study plan

HCG is introduced

Drug

must have good blastocysts

Other names: Improve results of IVF and embryo transfer

Primary outcomes

  1. HCG enhances pregnancy rate

    Time frame: 9 months.

    compare pregnancy rates to established clinical norms.

Secondary outcomes

  1. implantation rate

    Time frame: 18 months

    compare implantation rate per embryo to clinical norms.

  2. ongoing pregnancy rate

    Time frame: 22 months

    compare success to clinical norms

Sponsors and collaborators

Lead sponsor

Servy Massey Fertility Insititute

Other

Registry information

Official study title

Intrauterine Injection of Human Chorionic Gonadotropin to Enhance Embryo Implantation

Important dates

Study start
2013
Primary completion
2015
Study completion
2016
First posted
Nov 18, 2013
Registry last updated
Mar 19, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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