Skip to main content
OpenTrials
Completed

NCT Number: NCT04247334

Inhibitory Control: Effects of Modulation

Inhibitory control is relevant to many clinical disorders, including substance abuse/dependence, obsessive-compulsive disorder, and attention-deficit hyperactivity disorder. This proposal is designed to assess brain networks related to response inhibition in healthy young adults, and use neuromodulation to change these networks and behavioral performance on a response inhibition task. Having an understanding of the brain mechanisms involved in response inhibition may enable us to improve pre-existing treatments for disorders with inhibitory control difficulties.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Young Adults

Age range

18 year–25 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Butler Hospital

Providence, Rhode Island, 02906, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Low (<1sd below the mean on the BRIEF-Inhibit) or high (>1sd above the mean on BRIEF-Inhibit scale)
  • English fluency to ensure comprehension of study measures and instructions.

Exclusion criteria

  • Presence of medical conditions contraindicated for tDCS, including history of any known intracranial pathology, epilepsy or seizures, traumatic brain injury, brain tumor, stroke, implanted medical devices, current pregnancy or women of childbearing age not using effective contraception, or any other serious medical conditions or health problems that would interfere with participation (e.g., skin condition)
  • Inability to undergo MRI
  • Current substance abuse disorder
  • Currently prescribed psychiatric medications.
  • Active mania or psychosis

Treatment and study plan

Transcranial Direct Current Stimulation

Device

20 minutes of 2 milliamp transcranial direct current stimulation

Primary outcomes

  1. fMRI connectivity at rest

    Time frame: 2 weeks

    Changes in resting state connectivity of the inhibitory control information

  2. fMRI connectivity during a stop signal task

    Time frame: 2 weeks

    Changes in task-based connectivity on the stop signal task

Sponsors and collaborators

Lead sponsor

Butler Hospital

Other

Registry information

Official study title

Brain Circuitry of Inhibitory Control: Effects of Modulation

Important dates

Study start
2019
Primary completion
2024
Study completion
2024
First posted
Jan 30, 2020
Registry last updated
Jun 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.