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Completed

NCT Number: NCT03850288

Inhibitory Control and Eating Disorders

Executive functions are part of the high-level cognitive processes essential to the proper functioning of human cognition. They consist mainly of flexibility, updating and inhibition. Some studies have shown a correlation between executive disorders (impaired executive function) and psychiatric disorders such as obsessive-compulsive disorder or phobias. These executive disorders are related to dysfunctions of the fronto-striatal loops.

In addition, other studies have investigated the link that may exist between eating disorders such as anorexia or bulimia nervosa and executive functioning. Anorexia nervosa, bulimia nervosa and binge eating disorders are eating disorders characterized by a dysfunction in food intake with restriction of food or compulsions as well as strong concerns about the body schema. Concerning the executive functioning, these studies highlight a lack of cognitive flexibility for patients with anorexia nervosa and bulimia nervosa but also dysfunctions depending on the type of pathology (anorexia nervosa or bulimia nervosa). These studies also highlight the beneficial effects of cognitive remediation on people with eating disorders.

However, the investigation of the inhibitory control has not yet been specifically studied. Moreover, since eating disorders are structurally different, a comparison between several pathologies would be interesting to consider.

The aim of this study is to determine if a dysfunction of inhibitory control can be highlighted in people with eating disorders. This study would also allow further researches about cognitive remediation suitable for the specific difficulties encountered in these diseases.

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Key information

Conditions

Anorexia Nervosa Binge Eating Bulimia Bulimia Nervosa Feeding and Eating Disorders Hyperphagia Mental Disorders Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Digestive

Age range

19 year–40 year

Sex eligibility

Female

Study type

Observational

Primary location

Centre Référent pour l'Anorexie et les Troubles du Comportement Alimentaire

Bron, 69500, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Woman aged 19 to 40 years old
  • Patient with a BMI between 13 and 40 kg/m2
  • Outpatients of the Refering Center of Eating Disorders ('Hospices Civils de Lyon' in Lyon) suffering of an eating disorder diagnosis (Anorexia Nervosa, Bulimia Nervosa or Binge Eating Disorder)
  • Patient who agrees to participate to the study.

Exclusion criteria

  • Patient with psychiatric comorbidity severe (DSM V) and not stable (during the 8 weeks before inclusion)
  • Patient with psychotropic treatment (started or modified during the 8 weeks before inclusion)
  • Major patient protected by a measure of legal protection
  • Patient younger than 19 years old
  • Participation to another study at the same time

Treatment and study plan

Neuropsychological assessment : Stroop task

Other

Stroop task is an interference task assessing cognitive inhibitory control. This "paper-and-pencil" task aims to evaluate the inhibition of an automated process such as reading by asking participants to name the color of color names written in a different color ink.

This test is non-invasive.

Neuropsychological assessment : Go No Go task

Other

Go No Go task assessing motor inhibitory control. This computer-based task is designed to evaluate motor inhibition by asking participants to respond to a stimulus as quickly as possible by inhibiting another distractor stimulus.

This test is non-invasive.

Primary outcomes

  1. Inhibition processes assessment - the Stroop task, Execution time

    Time frame: 1 day

    Execution time in the Stroop task

  2. Inhibition processes assessment - the Stroop task, Errors

    Time frame: 1 day

    Errors in the Stroop task

  3. Inhibition processes assessment - the Go No Go task, Execution time

    Time frame: 1 day

    Execution time in the Go No Go task.

  4. Inhibition processes assessment - the Go No Go task, Variability of execution time

    Time frame: 1 day

    Variability of execution time in the Go No Go task

  5. Inhibition processes assessment - the Go No Go task, Errors

    Time frame: 1 day

    Errors in the Go No Go task

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

Inhibitory Control in Eating Disorders (Anorexia Nervosa, Bulimia Nervosa and Binge Eating Disorder)

Acronym: InhibEating

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Feb 21, 2019
Registry last updated
Mar 6, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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