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OpenTrials
Completed

NCT Number: NCT04397991

Inhaled Furosemide for Transient Tachypnea of Newborn

This is a randomized double blind clinical trial in which newborns with suspected Transient tachypnea of the newborn (TTN) will receive either furosemide or normal saline by nebulizer every 6 hours for 24 hours.

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Key information

Conditions

Respiratory Morbidity

Age range

1 day–1 day

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Makassed General Hospital

Beirut, Lebanon

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Neonates with 34+0-39+0 gestational age
  • on the first day of life
  • with the clinical diagnosis of Transient Tachypnoea
  • need for CPAP >6 hours to obtain the oxygen saturation >92%

Exclusion criteria

  • Systemic infection
  • Intubation and mechanical ventilation before Inclusion in the trail
  • Malformation and any other disease with disturb of respiratory system

Treatment and study plan

Furosemide

Other

Patients will receive nebulised furosemide solution 1 mg/kg

Placebo

Other

Patients will receive nebulised 0.9% saline

Primary outcomes

  1. Percentage of patients with respiratory morbidity

    Time frame: 24 hours

    Neonatal respiratory morbidity will be assessed through oxygen saturation, respiratory rate and duration on Continuous positive airway pressure (CPAP)

Secondary outcomes

  1. Length of hospital stay

    Time frame: 15 days

    Duration of hospital stay in days

Sponsors and collaborators

Lead sponsor

Makassed General Hospital

Other

Registry information

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
May 21, 2020
Registry last updated
Aug 30, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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