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Completed

NCT Number: NCT06297915

Infusion Treatments of Chronic Peripheral Neuropathic Pain

This study aimed to evaluate and compare the efficacy of ketamine and lidocaine infusion in patients with chronic peripheral neuropathic pain.

Patients who received intravenous ketamine infusion and the other patient group who received intravenous lidocaine infusion were evaluated in the study. Pain scores and quality of life were assessed with scales before treatment at two weeks, two months, and six months after treatment.

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Key information

Conditions

Neuropathic Pain Nervous System Diseases Neuralgia Neurologic Manifestations Neuromuscular Diseases Pain Pathological Conditions, Signs and Symptoms Peripheral Nervous System Diseases Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hacettepe University

Ankara, Cankaya, 06360, Turkey (Türkiye)

About this study

This study, it was aimed to evaluate and compare the efficacy of intravenous infusion of ketamine and lidocaine, which have been known and used in pain management and which have recently increased interest in the treatment of peripheric neuropathic pain.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-65 years of age
  • Patients with peripheral neuropathic pain (radicular neuropathy, diabetic neuropathy, complex regional pain syndrome type 2, traumatic peripheral nerve injury, trigeminal neuralgia, postherpetic neuralgia)
  • Patients who was evaluated by DN4 scores with of ≥4 points

Exclusion criteria

  • Patients with central nervous system disease .
  • Patients with cancer related neuropatic pain.
  • Patients with central neuropathic pain patterns.
  • Patients with renal, hepatic, cardiovascular, and psychiatric diseases.
  • Patients whose treatment could not be completed due to side effects or other reasons.
  • Patients who had lost their follow-up .

Treatment and study plan

ketamine

Drug

Ketamine infusion was administered at 1 mg/kg (in 1 hour)

Other names: Group K

Lidocain

Drug

Lidocaine infusion was administered at 3 mg/kg (in 1 hour)

Other names: Group L

Primary outcomes

  1. Neuropathic Pain Scale

    Time frame: Before treatment at two weeks, two months, and six months after treatment.The 7 symptoms items are scored by interviewing the patient.The scores are added and a score of 4 or more outout of ,10 point (severe pain ) is suggestive of neuropathic pain.

    Neuropathic Pain 4 Questions (DN4)

  2. Pain Rating Scale

    Time frame: Before treatment at two weeks, two months, and six months after treatment.NRS in which individuals rate their pain on an ten-point numerical scale. Zero:''no pain at all' ten-point ''severe pain''

    Numeric Rating Scale

Secondary outcomes

  1. Quality of Life Scale

    Time frame: Before treatment at two weeks, two months, and six months after treatment.12-question survey PCS and the MCS Scores above 50 indicate a better-than-average health-related quality of life, while scores below 50 suggest below-average health.

    Short form-12 (SF-12)

Sponsors and collaborators

Lead sponsor

Hacettepe University

Other

Registry information

Official study title

Evaluation and Comparison of the Effectiveness of Ketamine and Lidocaine Infusion in Peripheral Neuropathic Pain: A Retrospective Study

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Mar 7, 2024
Registry last updated
Mar 7, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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