Influenza Vaccine in HIV Study

The aims of this study are:

1. to investigate if HIV infection alters the antibody responses to influenza and 2. to assess the ability of licensed influenza vaccine to induce functional non-neutralising antibodies in HIV-infected and HIV-uninfected subjects.

Completed

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Key information

Conditions

Influenza, Human Infections Orthomyxoviridae Infections RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

HIV-1 positive by licensed diagnostic test (for HIV-positive group only)
Planning to receive the seasonal influenza vaccine outside the study
Provision of written informed consent

Exclusion criteria

Previous allergy to influenza vaccination
Pregnancy or planning to become pregnant
Unwilling or unable to provide blood samples

Treatment and study plan

2015 Fluvax® vaccine, BioCSL (a licensed influenza vaccine)

Biological

Subjects received licensed influenza vaccine (Fluvax®), 1ml intramuscular injection.

Primary outcomes

Anti-influenza antibody responses in plasma with Fc-mediated functions

Time frame: Four weeks after influenza vaccination

Sponsors and collaborators

Lead sponsor

University of Melbourne

Other

Registry information

Official study title

A Comparison of Immune Responses to the Licensed Trivalent Inactivated Influenza Vaccine in HIV-positive and HIV-negative Subjects

Important dates

Study start: 2015
Primary completion: 2015
Study completion: 2015
First posted: Dec 16, 2015
Registry last updated: Dec 16, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed