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Completed

NCT Number: NCT05084846

InFLUenza and the HEART An Investigation Into the Acute and Lasting Cardiac Effects of Influenza Infection

"Influenza and the Heart: An investigation into the acute and lasting cardiac effects of influenza infection" the investigators aim to assess the mechanisms for cardiovascular disease in patients suffering an acute influenza infection. The project will be carried out by creating a prospective clinical cohort study of consecutive patients hospitalized at Herlev & Gentofte University Hospital with a laboratory confirmed influenza.

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Key information

Conditions

Influenza Cardiovascular Complication Infections Influenza, Human Orthomyxoviridae Infections RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Herlev & Gentofte Hospital, Copenhagen, Denmark

Loading trial locations.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients hospitalized at Herlev & Gentofte University Hospital with a laboratory-confirmed diagnosis of influenza
  • > 18 years of age

Exclusion criteria

  • Persons not able to cooperate
  • Persons unable to understand and sign "informed consent"
  • Pregnancy
  • Persons simultaneously positive with COVID-19

Treatment and study plan

Primary outcomes

  1. Number of patients developing cardiovascular complications

    Time frame: 3 years

    Including new-onset heart failure, worsening of current heart failure, acute myocardial infarction, and cardiac arrest

  2. Number of patients developing in-hospital mortality

    Time frame: 3 years

  3. Rate of cardiac dysfunction

    Time frame: 3 years

    Defined by impaired echocardiographic parameters and elevated cardiac biomarkers - NT

    • pro
    • BNP annd hs
    • TNT

  4. Prevalence of elevated biomarkers of infection/inflammation

    Time frame: 3 years

    Prevalence of elevated biomarkers of infection/inflammation and it association with cardiac dysfunction

  5. Rate of pulmonary embolisms diagnosed with CT thorax angiography

    Time frame: 3 years

Sponsors and collaborators

Lead sponsor

University Hospital, Gentofte, Copenhagen

Other

Registry information

Official study title

Influenza and the Heart: An Investigation Into the Acute and Lasting Cardiac Effects of Influenza Infection

Acronym: FluHeart

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Oct 20, 2021
Registry last updated
May 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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